BACKGROUND Bile cast nephropathy(BCN)is suspected in the setting of liver disease and hyperbilirubinemia and is characterized by the formation of tubular bile casts and acute tubular injury.While postmortem studies re...
The gut microbiome comprises a vast community of microbes inhabiting the human alimentary canal,playing a crucial role in various physiological functions.These microbes generally live in harmony with the host;however,...
Supported by Innovation and Cultivation Fund Project of the Seventh Medical Center,PLA General Hospital,No.QZX-2023-7.
BACKGROUND The Kasai procedure(KPE)is an important treatment for biliary atresia(BA),the most common cause of neonatal obstructive jaundice.AIM To investigate the efficacy of robotic-assisted Kasai portoenterostomy(RA...
supported by funding fromÉcole Polytechnique Fédérale de Lausanne,Switzerland and Swiss National Science Foundation(SNSF 310030_212769 to K.S.).
The gut microbiome produces a plethora of metabolites that influence host metabolism.In a recent article published in Cell,Nie and colleagues reveal that 3-succinylated cholic acid,a microbe-derived bile acid,protects...
funded by National Research Council of Thailand (NRCT:N42A640330);supported by Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology
The aberrant hepatic duct is classified by Huang et al.[1]into type A(right intrahepatic duct variant)and type B(left intrahepatic duct variant).Type A and B are further classified into 5(A1-5)and 6(B1-6)subtypes,resp...
supported by a grant from the Key Program of the Independent Design Project of National Clinical Research Center for Child Health(Grant no.S20C0004);Shanghai Pujiang Program(21PJ1423100);Ministry of Industry and Information Technology Artificial Intelligence Medical Devices Innovation Program.
Background Biliary atresia(BA)is a rare fatal liver disease in children,and the aim of this study was to develop a method to diagnose BA early.Methods We determined serum levels of matrix metalloproteinase-7(MMP-7),th...
The concept of intraductal papillary neoplasm of the bile duct(IPNB)has gained recognition as a discrete entity[1,2],possessing many features including multiplicity[3,4],mucin production[3],slow progression[3,5],vario...
In this issue of Cell,Nie and co-authors report that the microbe-derived bile acid(BA)3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease.Intriguingly,its prot...