Protecting liver health with microbial-derived succinylated bile acids  

作　　者：Hadrien Demagny Alessia Perino Kristina Schoonjans 

机构地区：[1]Laboratory of Metabolic Signaling,Institute of Bioengineering,School of Life Sciences,École Polytechnique Fédérale de Lausanne,1015 Lausanne,Switzerland

出　　处：《Life Metabolism》2024年第5期38-41,共4页生命代谢（英文）

基　　金：supported by funding fromÉcole Polytechnique Fédérale de Lausanne,Switzerland and Swiss National Science Foundation(SNSF 310030_212769 to K.S.).

摘　　要：The gut microbiome produces a plethora of metabolites that influence host metabolism.In a recent article published in Cell,Nie and colleagues reveal that 3-succinylated cholic acid,a microbe-derived bile acid,protects against metabolic dysfunction-associated liver disease.The authors show that an increased abundance of the beneficial commensal microbe Akkermansia muciniphila,rather than enhanced bile acid signaling,drives this protective phenotype.

关 键 词：BILE protective LIVER 

分 类 号：R575[医药卫生—消化系统]