血清白细胞介素6和神经元特异性烯醇化酶与急性脑出血的关系研究  

Study of relationship between serum interleukin-6 and neuron-specific enolase concentrations in patients with acute intracerebral hemorrhage

作　　者：赵明哲[1] 庄向阳[1] 王杏儒[1] 王菁[1] 唐蕊[1] 李育臣[2] 

机构地区：[1]河北省石家庄市中心医院神经内科,050011 [2]河北医科大学第三医院神经内科

出　　处：《河北医药》2008年第5期597-600,共4页Hebei Medical Journal

基　　金：河北省科学技术研究与发展指导计划(编号:072761267)

摘　　要：目的探讨血清白细胞介素6(IL-6)和神经元特异性烯醇化酶(NSE)与急性脑出血(ICH)的体积、部位、神经功能缺损程度及患者年龄、性别等方面的关系。方法采用酶联免疫吸附法(ELISA)对50例急性脑出血患者发病后血清IL-6、NSE水平进行动态检测,并与40例对照组进行比较。结果脑出血患者在发病早期48h内血清IL-6、NSE浓度即明显升高,3～5d达到峰值,明显高于对照组(P<0.01),随后逐渐下降,IL-6至发病后6～9d接近对照组水平(P>0.05),而NSE在病程6～9d,甚至10～14d时仍明显高于对照组(P<0.01);脑出血患者急性期(发病1周内)血清IL-6、NSE平均含量与出血量大小及神经功能缺损程度呈显著正相关(P<0.01)。结论血清IL-6、NSE水平可以作为急性脑出血的早期诊断、判断病情转归和预后的综合指标,为ICH的抗炎治疗提供了理论基础。Objective To evaluate the significance of serum IL-6 and NSE concentrations in patients with acute ICH, and to explore the correlation between the two parameters and neurologic deficits, volume and site of hemorrhage , age and gender. Methods The serum levels of IL-6 and NSE were serially determined in 50 patients with ICH and 40 control subjects using enzyme-linked immunosorbent assay （ELISA）.Results Statistical analysis showed that the serum concentrations of IL-6 and NSE increased within 48 hours after ICH in ICH group; peaked at 3rd- 5 th. day; when compared with the control group, there were significant differences （ all P 〈 0.01 ）. Then they began to decrease gradually. The serum concentration of IL-6 decreased and close to the approximate normal level at 6 - 9th day. While the NSE level was still greater than that in control group at 10 - 14 day（ P 〈 0.01 ）. the NSE levels were obviously higher at 6 - 9th day,even at 10- 14th day than those of the control group, statistic significance existed between two groups（ P 〈 0.01）. There was a positive correlation between the mean level of IL-6, NSE in serum and the volume of hemorrhage, the scores of neurological function as assessed by SSS in the first week of ICH （all P 〈 0.01 ）. Conclusion The serum levels of IL-6 and NSE levels may be served as a comprehensive index of early diagnosis, evaluation of seriousness and prognosis in ICH, and they may provide a theoretical basis for the anti-inflammatory therapy in ICH.

关 键 词：脑出血 白细胞介素6 神经元特异性烯醇化酶 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R503[医药卫生—临床医学]