17染色体微卫星多态与原发性高血压关系的多因素分析  

Multivariate analysis on the relationship between polymorphisms on chromosome 17 and essential hypertension

作　　者：付凌雨[1] 赵彦艳[2] 时景璞[1] 李春义[2] 刘洪[2] 周波[1] 

机构地区：[1]中国医科大学附属第一医院临床流行病教研室,沈阳110001 [2]中国医科大学遗传教研室

出　　处：《中华流行病学杂志》2008年第6期522-525,共4页Chinese Journal of Epidemiology

基　　金：国家科技攻关计划资助项目（2002BA711A08,2004BA720A04）;国家自然科学基金资助项目（30671736）

摘　　要：目的 探索D17S1878和D17S932位点多态性是否与原发性高血压存在关联。方法 在高血压高发区收集67个原发性高血压家系的流行病学资料，应用遗传分析仪分析D17S1878、D17S932位点的多态性，进行表型不一致家系同胞的病例对照研究，应用logistic回归方法进行多因素分析。结果 高血压受累同胞与非高血压受累同胞相比，年龄、男性、饮酒、平均收缩压、平均舒张压、BMI、总胆固醇、HI）L—C、LDL—C均显著高于非高血压受累同胞（P〈0．05）。D17S1878多态性位点共有11个等位基因，其等位基因频率在家系高血压者与非高血压者的分布，经Fisher’s确切检验差异具有统计学意义（P=0．017）。D17S932多态性位点共有9个等位基因，其等位基因频率在家系高血压者与非高血压者的分布，经Fisher’s确切检验差异无统计学意义（P=0．559）。logistic多因素分析结果显示，两个位点均没有进入模型，而年龄（0R=1．044，95％CI：1．019～1．069）、饮酒（OR=2．644，95％CI：1．778～3．932）、性格急躁（OR=3．078，95％CI：1．721～5．504）、甘油三酯（OR=1．305，95％CI：1．016～1．676）、LDL—C（OR：1．787，95％CI：1．296～2．646）进入模型，是原发性高血压的危险因素。结论 在原发性高血压家系中，D17S1878、D17S932多态性位点可能与原发性高血压无关联。Objective To explore the relationship of polymorphisms of D17S1878,D17S932 sites and essential hypertension. Methods Sixty-seven pedigrees were collected at the region with high prevalence of hypertension. The polymorphisms of D17S1878 and D17S932 sites were genotyped using Genetic Analyzer and GeneScan Software. Case-control study in sibs with different phenotype was carried out and logistic analysis was used for multivariate analysis. Results There were significant differences on the distributions of age, male, drinking, average systolic pressure, average diastolic pressure, the characteristics of rash, body mass index （BMI）, total cholesterol amount, triglyceride,low density lipoprotein （LDL） between the hypertensive-affected sibs and the normotensive sibs （P〈 0.05）. There was significant difference between the affected hypertensive and normotensive sibs in the D17S1878 site （P〈 0.05）, while there was no significant difference in D17S932 （ P 〉 0.05）. After non-conditlonal logistic analysis, data showed that both sites were not included in the model, while age （OR = 1. 044,95 % CI： 1. 019-1. 069）, drinking （ OR = 2. 644,95 % CI ： 1. 778-3. 932 ）, the characteristics of rash （ OR = 3. 078, 95%CI：1.721-5.504）, triglyceride （OR= 1.305,95%CI： 1.016- 1.676）, LDL-C （OR= 1.787, 95% C1：1.296-2. 646）,as risk factors, were included in the model. Conclusion The polymorphisms of D17S1878 and D17S932 possibly were not associated with essential hypertension.

关 键 词：原发性高血压 微卫星多态 遗传易感性 

分 类 号：R544.1[医药卫生—心血管疾病] R195.1[医药卫生—内科学]