乳腺癌中Survivin和Ki-67的表达及其临床意义  

The expression and clinical significance of Survivin and Ki-67 in breast carcinoma

作　　者：仲雷[1] 张建国[1] 郭宝良[1] 陈晰[1] 罗国庆[1] 李智刚[1] 

机构地区：[1]哈尔滨医科大学附属第二医院乳腺外科,150086

出　　处：《中国医师进修杂志（外科版）》2008年第6期3-6,共4页Chinese Journal of Postgraduates of Medicine

基　　金：国家自然科学基金资助项目（30672420）;黑龙江省科技厅攻关项目（GB05C402-01）

摘　　要：目的 检测Survivin和Ki-67在乳腺癌中的表达，探讨两者的相关性及临床意义。方法 应用免疫组织化学法检测49例乳腺癌组织和12例正常乳腺组织中Survivin和Ki-67的表达。结果 Survivin和Ki-67在乳腺癌组织中的表达阳性率明显高于正常乳腺组织中的表达（P〈0．05）；Survivin的表达与患者的临床分期、淋巴结转移有关（P〈0．05），而与其他临床病理特征无关；Ki-67的表达与患者的临床分期、淋巴结转移和病理学分级有关（P〈0．05），而与其他临床病理特征无关；Survivin和Ki-67在乳腺癌组织中的表达呈明显相关性（r=0．734，P〈0．05）。结论 Survivin与Ki-67可能通过相互协同作用参与乳腺癌的发生、发展过程，可作为评价乳腺癌生物学行为的重要依据。Objective To investigate the expression and clinical significance of Survivin and Ki-67 in breast carcinoma,and explore their correlation. Method The expression of Survivin and Ki-67 in breast carcinoma （49 cases） and normal breast tissues （12 cases） were examined by immunohistochemical method. Results The positive expression rates of Survivin and Ki-67 in breast carcinoma were significantly higher than those in normal breast tissues（P 〈 0.05 ）. The expression of Survivin was significantly related to clinical stage and lymph node metastasis （P 〈 0.05）. The expression of Ki-67 was significantly related to clinical stage, lymph node metastasis, and pathological grade（P 〈 0.05 ）. The expression of Survivin was obviously related with Ki-67 in breast carcinoma （r = 0.734,P 〈 0.05 ）. Conclusions The overexpression of Survivin and Ki-67 may play a cooperative role in the occurrence and development of breast carcinoma. They may serve as useful markers for assessment of biological behavior of breast carcinoma.

关 键 词：乳腺肿瘤 KI-67抗原 生存素 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤] R739.41[医药卫生—临床医学]