肝硬化血清CA125测定的临床意义  

The Clinic Significance of Serum CA125 Level in Patients with Hepatocirrhosis

作　　者：王明友[1] 何芳[1] 胡建国[1] 杨力[1] 

机构地区：[1]宁夏医学院附属医院消化内科,银川750004

出　　处：《宁夏医学院学报》2008年第3期314-315,329,共3页Journal of Ningxia Medical College

摘　　要：目的探讨血清CA125水平测定在乙肝肝硬化中的临床意义。方法对乙肝肝硬化的60例患者及慢性胃炎、肠易激综合征患者30例进行血清CA125检测,并对肝硬化患者血清肝纤维化行五项检测。结果肝硬化患者血清CA125水平(259.3±211.4IU/L),高于正常对照组(13.5±9.3IU/L),P<0.05;有腹水的肝硬化患者高于无腹水肝硬化者,P<0.05;在不同的肝功能分级中,血清CA125水平逐级升高,其差异有统计学意义(P<0.05);CA125浓度与肝纤维化五项指标中Ⅲ型前胶原、Ⅳ型胶原呈正相关,与甘胆酸、透明质酸、层黏连蛋白无明显相关性。结论肝硬化血清CA125水平可作为判断肝功能损害程度的一种指标,对肝硬化腹水的检测有较高的敏感性,可用来判断肝纤维化程度。Objective To explore clinic significance of detecting the serum CA125 level in patients with hepatitis B cirrhosis. Methods The serum CA125 level were detected in 60 patients with hepatocirrhosis and the total 30 patients with chronic gastritiS, irritable bowel syndrome, simultaneously, the serum five markers of liver cirrhosis were detected in hepatocirrhosis patients. Results The serum CA125 level were higher in hepatocirrhosis than that in the control group（ P 〈 0.05）. The hepatocirrhosis with ascites group had significant difference than those without ascites group（ P 〈 0.05）. In different liver function classification, serum CA125 level in Child A group had significant difference compared with Child B group and Child C group（ P 〈 0.05）. Serum CA125 level had no relationship among glycocholic acid（CG）, hyaluronic acid（HA）, laminin（LN） .However,it has positive relationship between precollagen type Ⅲ（PC Ⅲ ） and collagen type Ⅳ（ Ⅳ C）. Conclusion Serum CA125 level in hepatocirrhosis can be a sensitive marker to assess the injury degree of hepatic fuction. CA125 level has a high sensitivity to detect the hepatocirrhosis patient with ascites, and it can be used to predict the severity of liver fibrosis in hepatocirrhosis.

关 键 词：CA125 肝硬化 腹水 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统]