兔VX_2软组织肿瘤MR肌纤维束成像研究  

MR Muscle Tractography Study on VX_2 Soft-Tissue Tumor in Rabbits

作　　者：李勇刚[1] 王仁法[2] 郭亮[1] 谢道海[1] 胡春洪[1] 郭茂凤[1] 褚伟[1] 陈剑华[1] 邢建明[1] 

机构地区：[1]苏州大学附属第一医院放射科,江苏苏州215006 [2]华中科技大学附属同济医院放射科,湖北武汉430030

出　　处：《苏州大学学报（医学版）》2008年第2期211-214,共4页Suzhou University Journal of Medical Science

摘　　要：目的探讨扩散张量成像(DTI)及MR肌纤维束成像用于诊断骨骼肌病变的可行性。方法20只新西兰大白兔,右侧后肢近段接种VX2肿瘤组织悬液制成肿瘤模型,行MRI常规扫描和DTI成像。重建肌纤维束成像,分析肿瘤不同区域及正常肌肉的部分各向异性值(FA)及体积比各向异性值(VrA),并与病理学检查结果作对照。结果所有兔后肢肌肉VX2肿瘤模型均成功建立,肿瘤中心实质区与坏死区、肿瘤周边区、邻近及对侧正常肌肉的FA值相比,差异均有高度统计学意义(P<0.01)。肿瘤实质区与坏死区、邻近及对侧正常肌肉的VrA值差异有高度统计学意义(P<0.01),与瘤周区的差异无统计学意义(P>0.05)。肿瘤邻近正常肌肉与对侧正常肌肉各参数值差异无统计学意义(P>0.05)。MR肌纤维束成像显示肿瘤对邻近肌肉的破坏及浸润表现为肌纤维束完整性中断、不规则。结论DTI及MR肌纤维束成像能用于评价骨骼肌肿瘤的内部结构特征及与周围组织的关系,有望应用于肌肉结构、功能及病变的研究。Objective To determine if diffusion tensor imaging （DTI） and muscle fiber tracts of muscle disease are feasible. Methods Twenty Newzealand white rabbits were implanted with 0.2 ml VX2 tumor tissue suspension in the right proximal thighs. MRI and DTI were performed on these rabbits and DTI of muscle fiber tracts in the muscles around the lesions were reconstructed. The fractional anisotropy（FA） and volume ratio anisotropy（VrA） of the tumor and the normal muscle were analyzed. The correlation study between MRI and pathological findings was done. Results All experimental animal models of rabbit VX2 soft tissue tumors were successfully established. The difference of FA between the central parenchyma area and the necrosis area, the peripheral area of the tumor, the adjacent and contralateral normal muscle was statistically significant （P〈0.01）. The VrA of the central parenchyma area of tumors had statistical difference with the necrosis area of tumors, the adjacent and contralateral normal muscle had difference （P〈0.01）, but had no statistic difference with the peripheral area of tumors （P〉0.05）. The difference of FA and VrA between the adjacent and contralateral normal muscle was not statistically significant （P〉0.05）. The arrangement of normal muscle was regular on DTI of muscle tract. The muscle around the tumor lesions muscle tumors as well was infiltrated and destructed, which demonstrated irregular and interrupted muscle fiber on tractography. Conclusion DTI is advantageous to demonstrate the structure of soft tissue and its border, which should be helpful in the structure and function research of muscle, as in the diagnosis of muscle diseases.

关 键 词：软组织肿瘤 动物模型 磁共振成像 扩散张量成像 

分 类 号：R738.704[医药卫生—肿瘤]