BMSC-HA/TCP修复牙槽骨缺损后牙齿移动的实验研究  

Tooth movement after restoration for alveolar bone defect with BMSC HA/TCP scaffold

作　　者：王荣[1] 孙正[2] 刘华松[2] 

机构地区：[1]北京市石景山医院口腔科,主治医师北京100043 [2]首都医科大学口腔医学院,教授北京100050

出　　处：《中华老年口腔医学杂志》2008年第1期35-37,共3页Chinese Journal of Geriatric Dentistry

基　　金：国家高技术发展计划(863计划)资助项目(2003AA326010)

摘　　要：目的:探讨小型猪牙齿在牙槽骨缺损修复区的移动情况。方法:选用6只实验用小型猪(8-10个月龄),在一侧前磨牙近中造成直径为15mm,高为10mm圆柱状的骨缺损区。获取小型猪的自体骨髓基质细胞,分离培养并诱导为成骨样细胞。将小型猪自体骨髓基质干细胞与生物复合体(60%羟基磷灰石+40%磷酸三钙)复合后,种植到骨缺损区。另一侧作为对照侧。术后14W用60g力牵引双侧第一前磨牙近中移动。于12W后测量双侧前磨牙的移动距离。进行配对t检验比较。结果:6只小型猪两侧第一前磨牙近中移动平均距离的差异无统计学意义(P>0.05)。结论:应用细胞支架构建方式,可修复小型猪的上颌骨缺损,修复后不会对牙齿移动产生不良影响。Objective：To observe the movement of miniature were obtained pig＇s teeth in the area of defective alveolar bone Methods：6 minipigs were selected, mesenchymal stem cells from each miniature were obtained pig, the bone defect （diameter 15mm, high 10mm） were made and filled with BMSC-scaffold. After 14weeks, Orthodontic appliances were fixed to mesially guide the maxillary first pre-molars. Result： The miniature pig＇s teeth were mesially moved in the section with BMSC-scaffold. There were no signifficant differences between two sides for the movement distance of the first pre-molars （P〉0.05）. Conclusions：It is a reasonable method to restore bone defect with BMSC scaffold. The mini pigs＇ teeth can be mesially moved in the area filled with BMSC scaffold.

关 键 词：牙移动 小型猪 骨髓基质细胞 骨髓基质干细胞 骨缺损 

分 类 号：R78[医药卫生—口腔医学]