1,2-二(2-吡啶甲酰胺基)苯的合成  

Synthesis of 1,2-bis(2-pyridinecarboxamido)benzene

作　　者：冯晓亮[1] 赵颖俊[1] 吾国强[1] 

机构地区：[1]浙江工业大学化学与制药工程系,浙江衢州324000

出　　处：《化学试剂》2008年第6期440-442,共3页Chemical Reagents

基　　金：浙江省教育厅科研项目(20061237)

摘　　要：以2-吡啶甲酸与邻苯二胺为原料,分别采用两种不同的方法合成了标题化合物。研究表明,亚磷酸三苯酯法具有操作简便、所得产品纯度高等特点。通过正交试验优化的反应条件为:反应温度120℃,反应时间3h,n(亚磷酸三苯酯):n(2-吡啶甲酸)=0.67:1,收率为82.5%。产品经HPLC分析,含量99.7%。化合物结构经MS、IR、1HNMR确证。1,2-Bis（2-pyridinecarboxamido）benzene was synthesized from 2-pyridinecarboxylic acid and 1,2-diaminobenzene by two different methods.The results showed that the method of triphenyl phosphite had many advantages,such as easiness of operation and high purity of the product.The factors affecting synthesis process were studied in detail by means of orthogonal tests.The optimum conditions were obtained as follows：a molar ratio of triphenyl phosphite and 2-pyridinecarboxylic acid at 0.67∶1,a reaction temperature of 120 ℃ and a reaction time of 3 h.The product was characterized by IR,MS and ^1HNMR.The purity of the product was 99.7% and the yield was 82.5%.

关 键 词：2-吡啶甲酸 1 2-二(2-吡啶甲酰胺基)苯 亚磷酸三苯酯 合成 

分 类 号：O626.32[理学—有机化学]