祛痰逐水法对实验性大鼠急性肺损伤的影响  

Protective Effect of Eliminating Phlegm and Fluid-purging Exercise on Lipopolysaccharide Induced Acute Lung Injury in Rats

作　　者：陆健[1] 张小虎[2] 区永欣[2] 古继红[2] 田丙坤[1] 

机构地区：[1]陕西中医学院,陕西咸阳712058 [2]广州中医药大学内经教研室,广东广州510405

出　　处：《中华中医药学刊》2008年第6期1347-1349,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:从《伤寒论》结胸证治的提示,探讨祛痰逐水法对大鼠内毒素性急性肺损伤(ALI)的影响。方法:脂多糖诱发ALI,随机分为5组,即模型组、十枣汤组、三物白散组、大陷胸汤组和空白对照组。检测大鼠肺组织湿干比、血清TNF-α以及组织病理学。结果:模型组肺组织湿干比高于药物干预组和空白组(P<0.05);血清TNF-α模型组也明显高于药物组和空白组(P<0.05);组织病理学损害药物组也较模型组轻。结论:祛痰逐水法能减轻实验性急性肺损伤大鼠的损伤。Objective. to study theprotective effect of eliminating phlegm and fluid - purging exercise on acute lung injury induced by lipopolysaccharide in rats. Methods： All models of rats were reproduced by injecting lipopilysaccharide into the vein. 40 male Wistar rats were randomly divided into 5 groups ： LPS group, control group, Shizaotang treatment group, Sanwubaisan treatment group and Daxianxiongtang treatment group. Tumor necrosis factor α （TNF -α） level in serum,and W/D were measured, respectively. Results： （TNF-α） level in serum is higher in LPS group than those in the control group （ all P 〈 0.05 ）. The pathologic changes of lung tissue under microscope in control group were higherthan those in LPS group. Conclusion： It is suggested that qutanzhushui fang can protect the lung of experimental ALI model.

关 键 词：祛痰逐水 动物实验 内毒素 急性肺损伤 

分 类 号：R-33[医药卫生]