HGF在肺腺癌与细支气管肺泡细胞癌的表达  

Study of HGF Expression in Lung Adenocarcinoma and Bronchiloalveolar Cell Carcinoma

作　　者：张宇[1] 陈韶华[2] 钭春凤[1] 饶远权[1] 刘杏娥[1] 王廷详 钦光跃[1] 

机构地区：[1]浙江医院,浙江杭州310013 [2]浙江大学医学院附属第一医院

出　　处：《浙江预防医学》2008年第7期1-2,8,共3页Zhejiang Journal of Preventive Medicine

摘　　要：目的研究肝细胞生长因子(HGF)在肺腺癌与细支气管肺泡细胞癌的表达。方法应用免疫组化方法检测44例Ⅰ期肺腺癌与32例细支气管肺泡细胞癌手术切除标本HGF的表达,并统计5年生存率。结果肺腺癌与细支气管肺泡细胞癌细胞HGF阳性表达率分别为66.3%与85.4%(P=0.012);肺腺癌与细支气管肺泡细胞癌细胞HGF染色积分为4.08±0.72与5.41±0.89,差异有统计学意义(P=0.009)。Ⅰ期肺腺癌与细支气管肺泡细胞癌的5年生存率为68.2%与81.3%,差异有统计学意义(P=0.045)。结论HGF在肺腺癌与细支气管肺泡细胞癌的表达存在差异。Objective To understand the hepatocyte growth factor bronchiloalveolar cell carcinoma （BAC）. Methods （HGF） expression in lung adenocarcinoma and method was used to exam HGF expression in tumor specimens from 44 lung cancer patients in stage I and 32 BAC patients, 5-year survival rate of all patients were analyzed. Results HCG expression rates in lung adenocarcinoma and BAC are 66.3 % and 85.4%, respectively （P = 0.012）. The staining integrals of lung adenocarcinoma and BAC are 4.08±0.72 and 5.41±0.89, respectivdy （P= 0.009） . 5-year survival rates of lung adenocarcinoma and BAC are 68.2% and 81.3%, respectively （P = 0.045）. Conclusion HGF expression in BAC is higher than in lung adenocarcinoma.

关 键 词：肝细胞生长因子 细支气管肺泡细胞癌 肺腺癌 

分 类 号：R734.2[医药卫生—肿瘤]