雌激素受体β在膀胱移行细胞癌中的表达及其临床意义  

Expression of Estrogen receptor-β in bladder transitional cell carcinoma and its clinical significance

作　　者：朱敏[1] 叶章群[2] 张先觉[1] 廖义翔[1] 包世新[2] 

机构地区：[1]华中科技大学同济医学院附属荆州中心医院泌尿外科,湖北荆州434000 [2]华中科技大学同济医学院附属同济医院泌尿外科

出　　处：《临床泌尿外科杂志》2008年第5期338-340,共3页Journal of Clinical Urology

摘　　要：目的:探讨雌激素受体β(ERβ)的表达与膀胱移行细胞癌生物学行为的关系。方法:应用免疫组化方法对72例膀胱移行细胞癌以及12例正常膀胱组织中的ERβ进行检测。结果:膀胱移行细胞癌组织中ERβ表达的阳性率为66.7%(48/72例),显著高于正常膀胱组织的16.7%(P<0.05),且ERβ的表达随肿瘤临床分期、病理分级的增高而增高,与性别及年龄无关。结论:膀胱移行细胞癌中ERβ的表达与肿瘤的发展密切相关,并预示着一种侵袭性的生物学行为,ERβ可作为了解膀胱移行细胞癌生物学行为的参考指标。Objective：To investigate the relationship between the expression of estrogen receptor-Band the biological behavior of bladder transitional cell carcinoma. Methods：Immunohistochemistry method was used to detect ERβ in specimen of bladder transitional cell carcinoma of 72 cases and 12 controls. Results： Strong ERβexpressions were noted in 66.7% （48/72） of tumors. Whereas, ERβ protein levels were reduced in normal bladder mulosa. The differences of the expression of ERβ between controls and BTCC were of significance statistically（P〈0.05）. The expression of ERβ increased with tumor grade and stage, but ERβ was not correlated with sex and age. Conclusion：The expression of ERβ is strongly associated with neoplastic progression in bladder transitional cell carcinoma and aggressive biological behavior. The expression of ERβ may be one of parameters for understanding the biological behavior of bladder transitional cell carcinoma.

关 键 词：膀胱移行细胞癌 雌激素受体Β 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]