PRP,BPBM联合GTR修复犬牙Ⅱ度根分叉病变的研究  

Effectiveness of Combining Platelet-rich Plasma,Bovine Porous Bone Mineral and Guided Tissue Regeneration in the Treatment of Mandibular Grade II Molar Furcations in Dogs

作　　者：詹暶[1] 张志兴[1] 闫福华[1] 

机构地区：[1]福建医科大学附属口腔医院牙周科,福州350002

出　　处：《福建医科大学学报》2008年第3期233-235,共3页Journal of Fujian Medical University

基　　金：福建省自然科学基金(2007J0271);福建医科大学第六批青年骨干教师基金(闽医大[2006]124号)

摘　　要：目的应用富血小板血浆(PRP)、多孔牛骨无机材料(BPBM)和引导组织再生术(GTR)联合修复犬牙Ⅱ度根分叉病变,探讨其是否能增强GTR的疗效。方法人工构建Beagle犬下颌第一磨牙和第二、三前磨牙Ⅱ度根分叉病变模型,随机采用GTR/PRP/BPBM(实验组)或GTR(对照组)治疗,12周后经组织学观察牙周组织再生情况。结果GTR组的新生牙骨质长度和新生牙槽骨面积分别为(57.7±7.8)%和(30.8±7.4)%,GTR/PRP/BPBM组为(76.3±10.1)%和(59.9±13.1)%,两组比较差别无统计学意义。结论在本实验条件下,PRP复合BPBM不能明显增强GTR对Ⅱ度根分叉病变的再生作用。Objective The purpose of this study was to evaluate the effectiveness of platelet-rich plasma（PRP）, bovine porous bone mineral （BPBM）and guided tissue regeneration （GTR） used in combination,compared to GTR alone in the treatment of grade Ⅱ molar furcation defects in dogs. Methods Class Ⅱ periodontal furcation defects model in six adult Bealge dogs were created surgically and subsequently treated with either GTR alone or a combination of GTR/BPBM/PRP. The animals were sacrificed at 12 weeks postsurgery for histologic analysis. Results The percentage of new cementum length and new alveolar area in GTR and GTR/BPBM/PRP was 57. 7±7.8, 76.3±10. 1 and 30.8±7.4, 59.9±13.1, No statistically significant differences were observed between the two groups. Conclusion The results suggested that PRP/ BPBM added no benefit to GTR in the treatment of grade Ⅱ molar furcation defects.

关 键 词：根分叉病变 引导组织再生 牙周 血小板 血浆置换 疾病模型.动物 

分 类 号：R783[医药卫生—口腔医学]