熊去氧胆酸对结肠癌细胞株Caco-2增殖及凋亡的影响  

Effects of UDCA on proliferation and apoptosis of colon cancer cell line Caco-2 in vivo

作　　者：徐静[1] 杨大明[1] 沈琴[2] 周金君[1] 孟宪镛[1] 

机构地区：[1]南通大学附属医院消化病实验室,江苏大学附属医院消化病科226001 [2]南通大学医学院生化教研室

出　　处：《江苏医药》2008年第6期614-616,共3页Jiangsu Medical Journal

摘　　要：目的通过观察熊去氧胆酸(UDCA)对结肠癌细胞株Caco-2增殖和凋亡的影响,以探讨其对结直肠癌化学预防的机制。方法体外培养人结肠癌细胞株Caco-2,用不同浓度UDCA进行UDCA干预,检测其对细胞增殖、凋亡的作用。结果随着UDCA浓度增高和作用时间延长,细胞增殖抑制率升高,凋亡比率增大。结论UDCA能抑制人结肠癌细胞株Caco-2增殖,促进其凋亡。Objective To study the mechanism of chemopreventive effect of ursocleoxycholic acid （UDCA） on human colon adenocarcinoma cell line Caco-2 in vivo. Methods UDCA preparations of different concentration were used in culture of human colonic adenocarcinoma cell line Caco-2, and their effects on cellular proliferation and apoptosis were observed. Results Cell proliferation and apoptosis were blocked by UDCA, which showed a significant positive association with the concentration and the duration of UDCA treatment. Conclusion UDCA produces a restrictive effect on cancer cell proliferation and enhances apoptosis in vivo.

关 键 词：熊去氧胆酸 结肠癌细胞株Caco-2 凋亡 

分 类 号：R735[医药卫生—肿瘤]