定量组织速度成像心肌速度梯度评价胸部放疗患者左心室心肌局部收缩功能的研究  

Myocardial Velocity Gradient Assessment of Left Ventricular Systolic Function in Patients with Thoracic Radiotherapy Using Quantitative Tissue Velocity Imaging

作　　者：张娜[1] 张连仲[1] 刘琳[1] 吴晓翠[2] 韩倩[2] 王跃伟[2] 牛波[2] 

机构地区：[1]河南省人民医院超声科,郑州市450003 [2]河南省人民医院放疗科,郑州市450003

出　　处：《中国超声医学杂志》2008年第6期510-513,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的探讨定量组织速度成像心肌速度梯度技术在评价胸部放疗患者左室收缩功能方面的临床应用价值。方法应用QTVI技术离线分析40例肿瘤患者和20例正常人左心室各心肌节段长轴方向和短轴方向上的速度曲线，并将40例胸部放疗肿瘤患者按照放疗进程分为2组：A组：2．7～3．3周、照射剂量30-40Gy；B组：4．1～5．5周、照射剂量50～60Gy；测量收缩期峰值运动速度（Vs），计算左心室长轴方向基底段与中段心肌速度梯度（MVG1）、中段与心尖段心肌速度梯度（MVG2）及短轴方向心内膜与心外膜心肌速度梯度（MVG3）等参数。结果A组、B组前壁、前间隔、后壁各节段MVG1、MVG2及MVG3均较对照组明显减低且差异有显著性（P〈0．05）；B组前壁、前间隔、后壁各节段MVG1、MVG2及MVG3较A组减低且差异有显著性（P〈0．05）；A组、B组侧壁、后间隔各节段MVG1、MVG2及MVG3较对照组略减低但差异无显著性（P〉0．05）；下壁各节段MVG1、MVG2及MVG3在3组之间比较，差异均无显著性（P〉0．05）。结论胸部放疗患者左室长轴和短轴方向局部心肌收缩功能存在一定程度的降低；定量组织速度成像心肌速度梯度可作为一种新方法对其进行评价。Objective To evaluate the clinic experimental value of myocardial velocity gradient （MVG） assessment of left ventricular systolic function in patients with thoracic radiotherapy using quantitative tissue velocity imaging （QTVI） . Methods There were 40 patients with thoracic radiotherapy and 20 healthy controls in this study. According to the process of radiotherapy, the 40 patients were divided into two groups： group A： radiotherapy time was 2.7-3.3 weeks, with dosage of 30-40 Gy; group B： radiotherapy time was 4.1-5.5 weeks, with dosage of 50-60Gy. Off line profiles of the left ventricular regional systolic velocity along long axis and short axis in the 40 patients and 20 healthy subjects were analyzed on QTVI. Regional systolic velocity （Vs） were measured at each segment of ventricular basal, middle and apical levels. MVGs （MVG1, MVG2, MVG3） were calculated respectively. Results MVG1, MVG2, MVG3 of group A and B in the anterior wall, anterior septum and posterior wall were significantly lower than those in the control group （P〈0.05） ; MVG1, MVG2, MVG3 of group B in the anterior wall, anterior septum and posterior wall were lower than those in group A with significant difference （P〈0.05 ）; MVG1, MVG2, MVG3 of group A and B in left lateral wall, posterior septum were lower than those in the control group without significant difference （P〉0. 05） ; MVG1, MVG2, MVG3 of the inferior wall and posterior wall in all groups had no significant difference （P〉 0. 05） . Conclusions The results in this study demonstrated that regional left ventricular systolic function was decreased in patients with thoracic radiotherapy. In QTVI, MVG could offer a new approach for evaluating regional left ventricular systolic function.

关 键 词：定量组织速度成像 心肌速度梯度 放射治疗 左心室功能 

分 类 号：R730.5[医药卫生—肿瘤]