急性白血病患者血浆TF、TFPI及IL-1β动态变化分析  

Analysis of the Dynamic Change of TF,TFPI and IL-1β in Plasma of Patients with Acute Leukemia

作　　者：孙冶[1] 吴日荷[1] 刘伟红[1] 黄金伟[1] 

机构地区：[1]丽水市中心医院,浙江丽水323000

出　　处：《中国实验血液学杂志》2008年第3期493-496,共4页Journal of Experimental Hematology

摘　　要：本研究旨在探讨血浆组织因子(TF)、组织因子途径抑制物(TFPI)和白介素-1β(IL-1β)在急性白血病(AL)患者病情进展、疗效观察及预后判断中的意义。用酶联免疫吸附方法(ELISA)测定20例健康体检者及24例AL患者化疗前血浆TF、TFPI、和IL-1β的含量,并测定初治AL患者在进行化疗第72小时、缓解3个阶段血浆TF、TFPI、和IL-1β的含量。结果表明:24例初治AL患者首次诱导化疗前血浆TF、TFPI、和IL-1β含量较正常对照组高,差异有显著性(p<0.01);化疗第72小时血浆TF和IL-1β含量明显高于首次诱导化疗前,有显著性差异(p<0.05),但血浆TFPI与化疗前相比明显下降,也有显著性差异(p<0.01);24例初治AL患者16例缓解,缓解组血浆TF、TFPI和IL-1β含量降至正常,与正常对照组比无显著性差异(p>0.05)。结论:TF、TFPI和IL-1β是判断急性白血病患者病情进展、疗效观察及预后的重要指标。This study was purposed to explore the significance of tissue factor （ TF）, tissue factor pathway inhibitor （IFPI） and interleukin -1β（IL-1β） in the evaluation of development, curative effect and prognosis of AL patients. ELISA was used to detect the levels of TF, TFPI and IL-1 β in plasma of 20 healthy individuals and 24 newly diagnosed AL patients. All the three indications of patients were measured in different stages including pre-chemotherapy phase, at 72 hours after chemotherapy, complete remission phase. The results showed that as compared with normal control, levels of TF, TFPI and IL-1β in plasma of AL patients during pre-chemotherapy phase were higher （p 〈0.01 ） ; as compared with pre-chemotherapy phase, levels of TF, IL-1 β were elevated at 72 hours after -chemotherapy （p 〈 0.05 ）. However, the levels of TFPI was much lower than that of 72 hours after chemotherapy （p 〈 0.01 ）. 16 out of 24 patients got complete remission, there was no difference of TF,TFPI and IL-1β between complete remission group and normal control group. It is concluded that the levels of TF, TFPI and IL-1β in plasma can be used as the indicators for understanding clinical features, evaluating disease status and predicting prognosis in acute leukemia patients.

关 键 词：急性白血病 血浆组织因子 组织因子途径抑制物 白介素-1Β 

分 类 号：R733.71[医药卫生—肿瘤]