急性白血病药物基因组学研究现况  

Research Update on Pharmacogenomics in Acute Leukemia——Review

作　　者：李璘 肖志坚 

机构地区：[1]中国医学科学院血液学研究所血液病医院；实验血液学国家重点实验室,天津300020

出　　处：《中国实验血液学杂志》2008年第3期704-711,共8页Journal of Experimental Hematology

基　　金：新世纪优秀人才资助计划(编号NCET-05-0173);863计划(编号2006AA02A405)资助

摘　　要：药物基因组学是一门旨在阐明药物疗效个体差异遗传学基础的新学科,根据这些遗传学信息来预测个体对某一药物的用药安全性和疗效,指导临床个体化治疗,从遗传学的角度为急性白血病的合理用药开辟了新的途径。本文对急性白血病治疗药物代谢、转运及作用靶点相关酶系编码基因的多态性与治疗不良反应及疾病预后之间关系的研究现况作一综述。Pharmacogenomics, a new subject aiming to elucidate genetic basis for inter individual differences in response on a drug and to predict the safety and efficacy of drugs by the genetic information, which guides to clinical individual therapy, breaks a new way to apply drugs rationally to acute leukemia. This article reviewed the enzymes related to metabolism, transport and acting point of the drugs used in the treatment of acute leukemia and discussed the influence of their coding gene＇s polymorphism on drug adverse effects and disease prognosis.

关 键 词：药物基因组学 基因多态性 白血病 

分 类 号：R733.71[医药卫生—肿瘤]