重性精神病患者弓形虫感染率调查及分析  

Comparative study on Toxoplasma infection in patients with major psychoses

作　　者：王惠玲[1] 李秋英[1] 王高华[1] 王晓萍[1] 舒畅[1] 郝世胜[1] 

机构地区：[1]武汉大学人民医院精神卫生中心,武汉430060

出　　处：《中国人兽共患病学报》2008年第6期589-591,共3页Chinese Journal of Zoonoses

基　　金：美国Stanley医学研究基金会资助项目(01T-435)

摘　　要：目的比较精神分裂症患者与情感障碍患者、正常对照组及躯体疾病对照组弓形虫抗体阳性率，分析弓形虫感染与精神分裂症的关系。方法用酶联免疫吸附法检测精神分裂症患者和情感障碍患者（各600例）、健康人和躯体疾病患者（各200名）血清弓形虫抗体水平，以透射比浊法检测血清总免疫球蛋白G（总IgG）的含量。结果（1）精神分裂症患者IgG抗体阳性率（13．7％），高于健康人（3．0％）、躯体疾病患者（4．5％）和情感障碍患者（6．7％），弓形虫IgG抗体阳性与精神分裂症的联系强度为中等（OR=2．22～5．13）；而精神分裂症患者IgM抗体阳性率与其它三组之间的差异无统计学意义。（2）情感障碍患者IgG和IgM抗体阳性率与健康人和躯体疾病患者均无显著性差异（P〉0．05）。（3）精神分裂症组和情感障碍组、躯体疾病对照组之间血清总IgG含量的差别无统计学意义（P〉0．05）。结论精神分裂症患者的弓形虫血清IgG抗体阳性率高于情感障碍和躯体疾病患者及健康人，弓形虫隐性感染可能与部分精神分裂症的发生有关。To explore the relationship between Toxoplasma infection and schizophrenia by comparing the prevalence of antibodies to Toxoplasma gondii （T. gondii） among the schizophrenia patients, the patients group with affective disorders, the normal control group and the patients group with physical diseases. Both six hundred cases of schizophrenia patients, and 600 eases of patients with affective disorders, 200 eases of normal controls and 200 eases of patients with physical diseases were examined for the serum reactivity to antibodies to T. gondii by ELISA. The serum level of total IgG of each group was also examined. The results showed that the positive rate of IgG antibody in the schizophrenic patients was 13.7%, which was higher than the affective disorder group, the normal control group and the physical disease control group. And the odds ratio of schizophrenia associated with IgG antibody was 2.2-5.12. However, there was no statistical difference in the rate of IgM antibody between schizophrenia group and the three control groups. The affective disorders group did not differ in the rate of IgG or IgM antibody from the normal or the physical disease control group. Mean while there was no significant difference in the concentration of serum total IgG among the schizophrenia group, the affective disorders group and the physical disease control group. These results suggest that Toxoplasma infection is a candidate etiological factor for at least part of schizophrenia, but not the result of change in behavior or lifestyle after schizophrenia. It is necessary to confirm the result by controlling the confounding factors, such as the course of the diseases.

关 键 词：精神分裂症 情感障碍 弓形虫病 抗体 

分 类 号：R749.3[医药卫生—神经病学与精神病学]