Correlative analysis between abnormal cervical cytology and pathology of vaginoscopic biopsy or conization  

作　　者：李彩娟 郎景和 程雪梅 王友芳 

机构地区：[1]Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College,Chinese Academy of Medical Sciences

出　　处：《生殖医学杂志》2006年第B10期69-73,共5页Journal of Reproductive Medicine

摘　　要：Objectives: To evaluate the predictive value of cervical intraepithelial neoplasia (CIN)III/ carcinoma in situ (CIS) by correlating analysis between abnormal cervical cytologic findings and pathological diagnosis of vaginoscopic biopsies or conization.Methods: Routine cervical cytology screening was performed in 31,634 cases by fluid-based thin-layer method (ThinPrep cytology test, TCT), 948 patients had both abnormal squamous cell appearance by TCT and pathological diagnosis of vaginoscopic biopsies and /or cervical conization. The predictive value of CINIII/CIS were studied retrospectively by correlating analysis of different cytology abnormalities and pathology diagnosis.Results: Cytologically, 1,260 out of 31,634 TCT tests showed abnormal squamous cells appearance, including atypical squamous cell of undetermined significance (ASCUS) 675 cases(2.13%), low squamous intraepithelial lesion (L-SIL) 379 cases(1.20%), high squamous intraepithelial lesion (H-SIL)176 cases(0.56%),cancer 30 cases (0.09%). Among 948 patients with pathological diagnosis, there were CINII-III in 70 cases(7.38%) and CINIII/CIS in 56 cases.(5.91%). The relative risks (RR) of different precancerous TCT results in predicting CIN III/CIS validated by pathology are as follow: AUSCUS 14.7% (95% confidence interval (CI) 8.0-27.0), Lsil 13.9% (95% CI 6.3-30.9), Hsil 126.1 (95% CI 60.6-218.6). The RR of AUSCUS group is not significantly different from that of L-SIL group(P =0.951). However, the RR of CINⅢ/CIS morbidity between the H-SIL or cancer group and the ASCUS or L-SIL group are significantly different (all P value <0.01).Conclusion: Vaginoscopic biopsy could verify pathological CINⅡ-Ⅲ and CINⅢ/CIS from cases with abnormal TCT results. There is significantly greater risk of being CINⅢ/CIS validated by vaginoscopic biopsy in the H-SILpatients,while ASCUS and L-SIL group have the coequal risk.Objectives： To evaluate the predictive value of cervical intraepithelial neoplasia （CIN）Ⅲ/ carcinoma in situ （CIS） by correlating analysis between abnormal cervical cytologic findings and pathological diagnosis of vaginoscopic biopsies or conization. Methods： Routine cervical cytology screening was performed in 31,634 cases by fluid-based thin-layer method （ThinPrep cytology test, TCT）, 948 patients had both abnormal squamous cell appearance by TCT and pathological diagnosis of vaginoscopic biopsies and/or cervical conization. The predictive value of CINⅢ/CIS were studied retrospectively by correlating analysis of different cytology abnormalities and pathology diagnosis. Results： Cytologically, 1,260 out of 31,634 TCT tests showed abnormal squamous cells appearance, including atypical squamous cell of undetermined significance （ASCUS） 675 cases（2.13 %）, low squamous intraepithelial lesion （L-SIL） 379 cases（1.20%）, high squamous intraepithelial lesion （H-SIL） 176 cases（0. 56%）,cancer 30 cases （0.09%）. Among 948 patients with pathological diagnosis, there were CINII-Ⅲ in 70 cases（7.38%） and CINⅢ/ CIS in 56 cases. （5.91%）. The relative risks （RR） of different precancerous TCT results in predicting CIN III/CIS validated by pathology are as follow： AUSCUS 14. 7% （95% confidence interval （CI） 8.0-27.0）, Lsil 13. 9%（95% CI 6.3-30.9）, Hsil 126.1 （95% CI 60.6-218.6）. The RR of AUSCUS group is not significantly different from that of L-SIL group（P =0. 951）. However, the RR of CINⅢ/CIS morbidity between the H-SIL or cancer group and the ASCUS or L-SIL group are significantly different （all P value 〈0.01）. Conclusion： Vaginoscopic biopsy could verify pathological CIN Ⅱ- Ⅲ and CIN Ⅲ/CIS from cases with abnormal TCT results. There is significantly greater risk of being CINⅢ/CIS validated by vaginoscopic biopsy in the H-SILpatients,while ASCUS and L-SIL group have the coequal risk.

关 键 词：子宫颈肿瘤 细胞学 病理学 活组织检查 

分 类 号：R737.33[医药卫生—肿瘤]