散发性大肠腺癌易感性与谷胱甘肽转硫酶P1基因型的关系  

Study on relationship between the genotype of glutathione S-transferase P1 and the susceptibility to sporadic colorectal adenocarcinoma(SCRAC)

作　　者：蓝德云[1] 蔡长江[1] 

机构地区：[1]浙江省温州市泰顺县人民医院内科,325500

出　　处：《浙江临床医学》2008年第6期726-727,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨中国汉族人群散发性大肠癌(SCRAC)易感性与谷胱甘肽转硫酶(GST)P1基因型的关系。方法采用聚合酶链反应技术(PCR)检测108例大肠癌患者和120例健康人群的GSTP1基因型,采用χ2检验,分析比较GSTP1基因型频率在SCRAC组和健康对照组之间的分布差异。结果GSTP1基因VaL/VaL基因型频率在SCRAC组中明显增高,与对照组相比,有显著性差异(43.5%vs30.8%,P=0.002,OR=0.430,95%CI:0.250～0.739);根据临床特征对SCRAC组进行分层分析,发现VaL/VaL基因型与SCRAC病变部位无关(P>0.05),但在DukesC期和低分化SCRAC患者中分布频率均明显增高(P<0.05)。结论GSTP1基因型与中国汉族人群SCRAC的易感性相关。Objective To investigate the relationship between the genotype of glutathione S - transferase Pl and the susceptibility to sporadic colorectal adenocarcinoma（SCRAC） in Chinese Hans. Methods Polymerase chain reaction（PCR） was used in the study of GSTP1 genotype, then the discrepancies of GSTP1 genotype frequencies were analysed between 108 SCRAC patients and 120 healthy controls by X^2 test. Results The frequency of VaL/VaL genotype was higher in the SCRAC patients than that in the controls （43.5 % vs30.8 %, P = 0. 002, OR = 0. 430, 95 % CI ： 0. 250 - 0. 739）. To stratificate the SCRAC patients by clinical features, we found there were no association between the frequency of VaL/VaL genotype and the location of SCRAC （ P 〉 0.05）. However, the VaL/VaL genotype of GSTP1 was significantly associated with colorectal adenocarcinoma of Dukes C classification （ X^2 = 7.380, P = 0.007, OR= 0.347,95%CI：0.160 - 0.753 ） and poor differentiation （ X^2 = 11.213, P = 0.001, OR = 0.270,95%CI：0. 124 - 0.590 ）, respectively.Conclusions The GSTP1 genotype is strongly correlated with the susceptibility to sporadic colorectal adenocarcinoma in Chinese Hans.

关 键 词：谷胱甘肽转硫酶P1 基因型 散发性大肠癌 易感性 

分 类 号：R735.34[医药卫生—肿瘤]