乳癌组织中细胞周期素G的表达  

Expression of Cyclin G in breast cancer tissue

作　　者：王蓉[1] 陈建中[1] 毛书明[2] 

机构地区：[1]郑州大学第二附属医院乳腺外科,郑州450014 [2]河南省肿瘤医院乳腺科,郑州450003

出　　处：《郑州大学学报（医学版）》2008年第3期506-509,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨乳癌组织中细胞周期素G(Cyclin G)的表达及临床意义。方法:应用免疫组织化学SP法检测88例乳癌组织及40例非癌区乳腺组织中Cyclin G的表达情况,并分析其与相关临床病理指标的关系。结果:乳癌组织和非癌区乳腺组织中Cyclin G的阳性表达率分别为38.6%、2.5%,差异有统计学意义(P<0.05)。乳癌组织中Cyclin G的过表达与肿瘤大小、组织学分级及P53的表达无关,而与淋巴结转移、绝经状态、激素受体有关(P<0.05)。结论:Cyclin G的异常表达可能与乳癌的发生、发展有关,可作为判断乳癌淋巴结转移倾向的参考指标。Aim：To investigate the expression of Cyclin G in breast cancer and its clinical significance. Methods：The expression of Cyclin G was detected by immunohistochemical SP method in 88 cases of breast cancer tissue and 40 cases of adjacent normal breast tissue ,and its correlation with the clinical-pathological features was analyzed. Results ：The positive rate of Cyclin G was 38.6% in breast cancer tissue and 2.5% in adjacent normal breast tissue,and there was significant difference between the two groups（ P 〈 0.05 ）. The over-expression of Cyclin G was not correlated with tumor size, histological grade and expression of P53 （P 〉 0.05 ） in breast cancer tissue,but correlated with lymph node metastasis, menopausal status and hormone receptor status （ P 〈 0.05 ）. Conclusion ： The over-expression of Cyclin G is probably correlated with the occurrence and development of breast cancer,and it can be servea as an index for the tendency of lymph node metastasis of breast cancer.

关 键 词：细胞周期素G 乳癌 

分 类 号：R737.9[医药卫生—肿瘤]