Interactions of the HSV-1 UL25 Capsid Protein with Cellular Microtubule-associated Protein  

作　　者：Lei GUO Ying ZHANG Yan-chun CHE Wen-juan WU Wei-zhong LI Li-chun WANG Yun LIAO Long-ding LIU Qi-han LI 

机构地区：[1]Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming 650118, China

出　　处：《Virologica Sinica》2008年第3期211-217,共7页中国病毒学（英文版）

基　　金：National Natural Science Funds(30570081, 30670094 and 30700028)

摘　　要：An interaction between the HSV-1 UL25 capsid protein and cellular microtubule-associated protein was found using a yeast two-hybrid screen and β-D-galactosidase activity assays. Immunofluorescence microscopy of the UL25 protein demonstrated its co-localization with cellular microtubule-associated protein in the plasma membrane. Further investigations with deletion mutants suggest that UL25 is likely to have a function in the nucleus.An interaction between the HSV-1 UL25 capsid protein and cellular microtubule-associated protein was found using a yeast two-hybrid screen and β-D-galactosidase activity assays. Immunofluorescence microscopy of the UL25 protein demonstrated its co-localization with cellular microtubule-associated protein in the plasma membrane. Further investigations with deletion mutants suggest that UL25 is likely to have a function in the nucleus.

关 键 词：HSV-1 CAPSID UL25 Microtubule-associated protein 

分 类 号：Q51[生物学—生物化学] Q26