高频透热联合肝动脉化疗栓塞治疗晚期原发性肝癌的临床研究  

Clinical investigation of RF transparent heating combined with TACE in the treatment of advanced primary hepatic carcinoma

作　　者：白桦 申维玺 窦永充 张彦舫 郑瑾 郑涛 叶建增 徐敏 

机构地区：[1]暨南大学第二临床医学院深圳市人民医院肿瘤研究所,518020

出　　处：《中国医师进修杂志》2008年第6期4-6,共3页Chinese Journal of Postgraduates of Medicine

基　　金：深圳市科技计划（200703275）

摘　　要：目的观察高频透热联合肝动脉化疗栓塞治疗晚期原发性肝癌的疗效及不良反应。方法随机将69例晚期原发性肝癌患者分为两组：对照组35例，单纯行动脉化疗栓塞治疗，从导管注入顺铂80mg，氟尿嘧啶1000mg，表阿霉素60mg，其中将表阿霉素与碘化油10柚混合乳化后行栓塞。治疗组34例，行动脉化疗栓塞治疗后再行局部高频透热治疗。结果治疗组近期疗效总有效率为70．59％，对照组为45．71％。两组比较差异有统计学意义。治疗组0．5、1．0、1．5、2．0年生存率分别为82．35％、73．53％、58.82％、38．24％，对照组分别为74．29％、75．14％、45．71％、22．86％。治疗组有增高的趋势。两组不良反应相近。结论高频透热联合肝动脉化疗栓塞治疗晚期原发性肝癌优于单纯肝动脉化疗栓塞，且不增加不良反应，是一种安全、有效的综合治疗方法。Objective To observe the efficacy and toxicities of RF transparent heating （RTH） combined with transcatheter hepatic arterial chemoembohzation （TACE） in the treatment of advanced primary hepatic carcinoma. Methods In a randomized manner, 69 patients with advanced primary hepatic carcinoma were divided into two groups： study group （TACE ＋RTH） 34 cases and control group （TACE alone） 35 cases, the control group were treated with DDP 80 mg, FU 1000 mg and E-ADM 60 mg, E-ADM was used with iodized oil embolism 10 ml. Results The total effective rate in the near future were 70.59% and 45.71%, the overall survival rates of 0.5, 1.0, 1.5, 2.0 years were 82.35%, 73.53%, 58.82%, 38.24% in study group and 74.29%, 75.14%, 45.71%, 22.86% in control group, respectively. Toxicities were similar comparing with the two groups. Conclusions RTH combined with TACE in the treatment of advanced primary hepatic carcinoma is better than TACE alone, at the same time TACE ＋RTH method is no increasing toxicity and is an effective safe combined one.

关 键 词：肝肿瘤 高频透热 肝动脉化疗栓塞 

分 类 号：R735.7[医药卫生—肿瘤] R697.330.5[医药卫生—临床医学]