γδT细胞在细胞免疫治疗骨肉瘤中的潜在作用  

Potential founction of γδT lymphocytes for cellular immunotherapies in osteosarcoma

作　　者：曹贞国(综述)[1] 叶招明(审校)[1] 

机构地区：[1]浙江大学医学院附属第二医院骨科,杭州310009

出　　处：《国际肿瘤学杂志》2008年第5期388-391,共4页Journal of International Oncology

摘　　要：γδT细胞是T淋巴细胞中一类数量比较少的细胞，不受MHC Ⅰ、Ⅱ类分子以及相关抗原肽配体限制，可直接识别抗原，分泌细胞因子溶解靶细胞，具有广泛的抗肿瘤活性。在骨肉瘤患者中，γδT细胞可通过识别骨肉瘤细胞表面相关抗原，溶解杀灭肿瘤细胞。未来以γδT细胞为基础的细胞免疫疗法联合手术、化疗等方法可在较大程度上提高骨肉瘤患者生存率。γδT lymphocytes, a numerically small subset of T lymphocytes, have been shown to directly recognize protein antigens without restriction by polymorphic MHC class Ⅰ or class Ⅱ molecules and their associated peptide ligands, secrete cytokines, kill tumor cells and display cytolytic activity against various tumors. In osteosarcoma patients, γδT lymphocytes can recognize antigens expressed on the surface of osteosarcoma cells, lyse and kill tumor cells. Combined with converntional chemotherapy and surgery, the new γδT lymphocytes-based cell immunotherapy of osteosarcoma can increase the survival rate greatly.

关 键 词：骨肉瘤 受体 抗原 T细胞 γ-δ 免疫 细胞 免疫疗法 

分 类 号：R738.1[医药卫生—肿瘤]