癌性恶病质内科治疗进展  

Medical treatment of cancer cachexia

作　　者：张红欣(综述)[1] 张增叶(综述)[2] 姜达(审校)[1] 

机构地区：[1]河北医科大学第四医院肿瘤内科,石家庄050011 [2]河北医科大学第三医院肿瘤内科

出　　处：《国际肿瘤学杂志》2008年第5期391-394,400,共5页Journal of International Oncology

摘　　要：癌症恶病质是晚期肿瘤患者常见综合征，是肿瘤组织与机体相互作用的结果，肿瘤组织产生炎性细胞因子及特定因子作用于机体，而机体应激产生全身急性反应及神经内分泌反应，如此相互作用导致恶病质。同时，患者的年龄、体力活动水平和肌肉蛋白的异常代谢也被认为与癌性恶病质发生相关。目前，临床治疗癌性恶病质的策略主要针对改善患者的厌食症状，随着对发病机制深入了解，一些具有明确靶点的药物研究成为热点。Cancer cachexia is a common syndrome in advanced cancer patients. It is the interactive result between tissue of tumor and organism. Tissue of tumor affects organism by producing cytokines and special tumor agents, meanwhile the reaction of acute phase and aeuroendocrine reaction happen in all over the body. Age, physical activity level and abnormal metabolism of muscle protein of patients are also correlated to cancer cachexia. Now clinical strategy to cancer cachexia is to improve symptoms of patients, such as anorexia, and so on. Along with elucidating the nosogenesis.of cancer cachexia, the research of drugs having identified targets becomes focus.

关 键 词：恶病质 药物疗法 营养支持 

分 类 号：R730.6[医药卫生—肿瘤]