红树林细菌Bacillus sp．次生代谢产物研究  

Secondary metabolites from a mangrove bacterium Bacillus sp.

作　　者：唐金山[1] 高昊[2] 洪葵[3] 姜苗苗[1] 周光雄[2] 王乃利[1] 姚新生[1] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]暨南大学中药及天然药物研究所,广东广州510632 [3]中国热带农业科学院热带作物生物技术国家重点实验室,海南海口571101

出　　处：《中国药物化学杂志》2008年第3期206-209,共4页Chinese Journal of Medicinal Chemistry

基　　金：国家自然科学基金-广东省人民政府联合基金项目(U0633008)

摘　　要：目的研究红树林细菌Bacillussp.发酵液中的化学成分。方法采用各种色谱方法进行成分分离,综合运用多种波谱学手段确定单体化合物的结构。结果从一株红树林细菌Bacillussp.的发酵物中分离得到6个单体化合物和一个混合物,单体化合物分别鉴定为N-oleoyl-threonine(1)、大豆素(2)、尿嘧啶(3)、胸腺嘧啶(4)、腺嘌呤核苷(5)、腺嘌呤脱氧核苷(6),混合物鉴定为环(脯-甘)二肽(7)和1,5-dideoxy-3-C-methyl-arabini-tol(8)。结论化合物1、8为首次从该属菌株中分离得到。Aim To study the chemical constituents of a mangrove bacterium Bacillus sp. Methods Various chromatographic and spectroscopic methods were applied for the isolation and structure identification of the compounds. Results Six compounds were obtained and their structures were identified as N-oleoyl-threonine （1）, daidzein（2）, uracil（3）, thymine（4）, adenosine（5）, and deoxyadenosine（6）, respectively. A mixture was also obtained and identified as [cyclo（Pro-Gly）]（7） and 1,5-dideoxy-3-C-methyl-arabinitol（8）.Conclusion Compounds 1 and 8 were firstly isolated from the genus of Bacillus.

关 键 词：结构鉴定 柱色谱法 红树林细菌 芽孢杆菌属 化学成分 发酵液 

分 类 号：R284.1[医药卫生—中药学]