外照射联合^131I-chTNT对小鼠Lewis瘤影响的研究  

Effect of irradiation combined with ^131I-chTNT on Lewis tumor of mice

作　　者：张明[1] 高献书[1] 张春丽[2] 秦尚彬[2] 刘朝兴[1] 王荣福[2] 

机构地区：[1]河北医科大学,石家庄050011 [2]北京大学第一医院

出　　处：《中华放射医学与防护杂志》2008年第3期255-257,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的研究外照射联合^131I-chTNT对荷瘤小鼠肿瘤生长的影响，并观察其在小鼠体内的分布和显像。方法建立C57小鼠Lewis瘤模型，肿瘤直径达一定大小时随机分组进行实验。测量给药后不同时间肿瘤组织及感兴趣器官的放射性，观察活体显像情况及荷瘤小鼠肿瘤生长延迟效应。结果联合外照射组肿瘤组织的放射性1、3和5d均高于单药组，组间差异有统计学意义（P值分别为0．018、0．041和0．024），两组中正常组织的放射性差别无统计学意义（P〉0．05）。联合组肿瘤区核素显像比单药组强且持续时间长。肿瘤生长效应实验中单药组、外照射组、联合组的绝对延迟时间为3．1、9．1和13．1d，标准化延迟时间为10d，^131I-ch TNT对放射的增益因子为1．08。结论外照射联合^131I-chTNT后可促进其在小鼠体内肿瘤区的浓聚，而对正常组织无影响。联合应用^131I-chTNT可提高外照射对荷瘤小鼠的放射效应。Objective To investigate the biodistribution and scintigraphy of Lewis carcinoma of mice with ^131I-chTNT combined with or without irradiation, and to study the effects on the tumor growth of mice. Methods When the tumor size in C57 mice beating Lewis carcinoma in the right leg was big enough, the mice were randomly divided into different groups to receive different treatment. The biodistribution and scintigraphy of ^131I-chTNT were observed at various time after tail-intravenous injection in tumor-bearing mice. The effect of treatment was assessed by tumor growth delay. Results The uptake of ^131I-chTNT in tumor tissue was significantly higher in combined group than in ^131I-chTNT group （ P 〈 0.05） and there were no more side effects in the combined group （ P 〉 0.05）. The scintigraphy result showed higher tumor accumulation of ^131I-chTNT in combined group than that in ^131I-chTNT group. The absolute growth delay for irradiation group, ^131I-chTNT group and the combined group was 9. 1, 3. 1 and 13.1 days, respectively. The nominal growth delay was 10 days, and the enhancement factor of ^131I-chTNT for RT was 1.08. Conclusions ^131I-chTNT combined with irradiation can increase the uptake of ^131I-chTNT in tumor without side effects.^131I-chTNT can enhance the radiotherapeutic effect for tumor-bearing mice.

关 键 词：小鼠 Lewis瘤 照射 ^131I-CHTNT 

分 类 号：R73-3[医药卫生—肿瘤]