甘氨双唑钠对恶性肿瘤放射增敏的临床研究  

Clinic study of CMNa radiosensitivity enhacement on malignant tumors

作　　者：蔡勇[1] 李东明[1] 孙艳[1] 苏星[1] 刘长青[1] 肖绍文[1] 铁剑[1] 徐博[1] 张珊文[1] 

机构地区：[1]北京大学临床肿瘤学院北京肿瘤医院放疗科,100036

出　　处：《中华放射医学与防护杂志》2008年第3期260-261,共2页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的评价甘氨双唑钠（sodium glycididazole，CMNa）在恶性肿瘤的放射增敏作用及安全性。方法对符合CMNa Ⅳ期临床研究的80例诊断明确的实体瘤患者采用三维适形放疗（three dimensional conformal radiotherapy，3D—CRT）或常规放疗，2Gy/次，5次/周，中位照射剂量60Gy，同期应用CMNa800ms／m^2，每周3次；观察肿瘤近期疗效和毒性作用。结果宫颈癌的近期疗效最好，有效率91．7％，其后依次是鼻咽癌85．7％、食管癌66．7％、肺癌54．5％、肝胆癌40％，全部有效率（CR＋PR）62．6％，疾病控制率（CR＋PR＋SD）达到100％；黏膜、皮肤的不良反应最常见，但多为1-2级轻度反应，分别为51．3％和46．3％；血液毒性白细胞下降最明显，但与治疗前相比差异无统计学意义（Χ^2=3．329，P=0．061），对肝肾功能、心电图变化均无明显影响。结论放疗结合CMNa治疗恶性肿瘤有满意的近期疗效，无明显毒性反应。Objective To evaluate the effects and safety of CMNa on radiosensitivity enhaeement for malignant tumors. Methods According to the standard protocol of CMNa IV stage clinic trial, 80 patients with malignant tumors were treated with 3DCRT or conventional radiotherapy, 2 Gy/fraetion and five fractions weekly. Concomitance CMNa were applied in intravenous 800 mg/m^2 , three times weekly. The treatment effects and side- effects were observed. Results The curative effect rates were 91.7% for cervical cancer, 85.7% for nasopharynx cancer, 66.7% for esophageal cancer, 54.5% for lung cancer, 40% for liver and gall cancer. The total curative effect rate was 62.6% and the tumor control rate was 100%. The side-effects occurrence rates of mueosa and skin which were grades 1 to 2, were 51.3% and 46.3% ,respectively,which were the highest in all side-effects. There were no statistical signifieanees between before and after treatment on the side-effects and blood test. Conclusions CMNa combined with radiotherapy can enhance the control rates of tumors with low toxicity and high safety.

关 键 词：甘氨双唑钠 放射治疗 恶性肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]