微血管病变患者血清学检测的临床意义  

Serum diagnosis in micrangium damage

作　　者：俞小忠[1] 吴怀志[1] 史有松[1] 马勇[1] 刘健虎[1] 

机构地区：[1]解放军第123医院内科

出　　处：《蚌埠医学院学报》1997年第5期346-347,共2页Journal of Bengbu Medical College

摘　　要：目的：了解微血管病变患者血清洋地黄样物质（ＥＤＬＳ）与超氧化物歧化酶（ＳＯＤ）的关系及其意义。方法：应用放射免疫法检测微血管病变患者血清ＥＤＬＳ、ＳＯＤ含量，酶法检测血清甘油三酯、胆固醇水平。结果：１５例正常对照者血清ＥＤＬＳ、ＳＯＤ浓度为０．３９±０．０７μｇ／Ｌ、４２２±１２７μｇ／Ｌ，２８例糖尿病患者、１８例脑出血患者、２３例脑梗塞患者血清ＥＤＬＳ浓度分别为０．５５±０．１４μｇ／Ｌ、０．６４±０．１３μｇ／Ｌ、０．７１±０．１８μｇ／Ｌ；ＳＯＤ浓度分别为３４２±９８、２９５±１３０、３０１±１２５μｇ／Ｌ。结论：微血管病患者血清ＥＤＬＳ浓度升高，ＳＯＤ浓度降低，随治疗好转，ＥＤＬＳ与ＳＯＤ恢复正常，检测ＥＤＬＳ与ＳＯＤ对诊断与指导治疗有一定意义。Objective:To investigate the relation between endogenous digitalis like substances(EDLS) and superoxide dismutase(SOD) in patients with damage of micrangium.Methods:EDLS SOD were detected by radioimmunoassay(RIA) in patients with damage of micrangium.Results:The results showed that the serum EDLS and SOD in normal controls were 0.39±0.07 μg/L and 422±127 μg/L respectively.The serum EDLS and SOD in the patients with diabetic(28 cases),cerebral hemorrhage(18 cases) and cerebral infarction(23 cases) were 0.55±0.14 μg/L,0.64±0.13 μg/L,0.71±0.18 μg/L,and 342±98 μg/L,295±130 μg/L,301±125 μg/L respectively.Conclusions:Serum EDLS and SOD change in perverse order in patients with damage of micrangium,EDLS increased whereas SOD decreased.EDLS and SOD became normal with the improvement of disease.EDLS and SOD measurements are therefore valuable for diagnosis and treatment in patients with damage of micrangium.

关 键 词：洋地黄样物质 超氧化物歧化酶 微血管病变 血清 

分 类 号：R743[医药卫生—神经病学与精神病学] R446.62[医药卫生—临床医学]