简易快速海洛因依赖脱毒的临床研究  

Clinical research on way of detoxification with simple and rapid in heroin dependence

作　　者：龚国如 邹晓敏 宋娟 陶纪武 胡玉珍 江红 易锐 

机构地区：[1]孝感市药物依赖治疗中心,湖北孝感432000

出　　处：《中国药物滥用防治杂志》2008年第3期140-142,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:寻求和验证简易快速躯体脱毒方法,为快速进入纳曲酮防复吸治疗打好基础。方法:前期以非阿片类药物进行3-4天脱毒治疗,继之以丙泊酚注射液200-400mg间断静脉推注,使患者维持在麻醉状态。然后静推纳洛酮注射液0.8-1.2mg,以后每隔10-15分钟静推1.2mg,连续3-6次后停止使用纳洛酮,整个过程持续1-2小时,待患者清醒后返回病房。结果:所有168例患者均顺利完成快速躯体脱毒治疗,术中除心率及血压有显著性变化外,呼吸、血氧饱和度及瞳孔等都无明显变化,术中患者反应平稳,无明显躁动、呕吐等现象;患者从开始治疗至清醒时间为1.83±0.67h;术前术后各项检查结果无明显差异;术中术后无严重并发症及不良反应;168例患者脱毒成功率达100%。结论:该脱毒方法简便、快速、安全、易于操作、疗效肯定,且能快速进入纳曲酮防复吸治疗。Objective： To seek and verify the way with simple rapid detexification, in order to prevent from repeat Naltrexone taking quickly. Methods： Firist, patients were assigned to take non-opioid detoxification for 3-4 days, then Propofol injection was inject 200-400mg in vein interval, patients were in state of anesthesia, and then inject Naloxone injection 0.8-1.2mg.Patients were injected 1.2mg during 10-15 minutes, stop performance Naloxone injection after continuous 3-6times. All continuous 1-2 hours, patients were back hospital room when patients had conscious. Results： All 168 patients performed successful rapid body detoxification, respire, degree of blood oxygen saturation and pupil show no significantly changes except heart rates and blood pressure show significantly changes, patients reacts were smooth ,no obvious mania and vomit; patients time is 1.83±0.67h between treatment begin to conscious emerge. Examination result show no significantly differences pre and post operation, no serious compliance and side effect during and post operation. Rate of detoxification is 100%. Conclusions： The way of detoxification is simple, rapid and performance easy, efficacy may be good, may rapid performed prevent from repeat take, were benefit to perform.

关 键 词：海洛因依赖 简易 快速脱毒 纳洛酮 

分 类 号：R749.64[医药卫生—神经病学与精神病学]