Ⅱ型糖尿病人角膜内皮细胞形态计量学研究  

A Quantitative Morphometric Study of Corneal Endothelium in Type Ⅱ Diabetes

作　　者：李贵仁[1,2] 陶祥臣[1,2] 李勤新[1,2] 王杰[1,2] 

机构地区：[1]潍坊医学院附属医院眼科 [2]济南中心医院眼科

出　　处：《眼科研究》1997年第3期186-188,共3页Chinese Ophthalmic Research

摘　　要：目的研究Ⅱ型糖尿病人角膜内皮细胞形态计量学变化。方法应用非接触式角膜内皮显微镜及细胞形态定量分析系统对７２眼（３６例）Ⅱ型糖尿病人角膜内皮细胞进行形态计量学分析。结果Ⅱ型糖尿病人角膜内皮细胞密度较对照组无显著性差异（Ｐ＞０．０５）。但细胞变异系数增大，六边形细胞比率和数据系数减少（Ｐ＜０．０５），非六边形细胞比率增大（Ｐ＜０．０５）。结论Ⅱ型糖尿病人角膜内皮细胞形态显著异常。血—房水屏障受损，房水内葡萄糖含量升高，可能与角膜内皮细胞变化有关。ObjectiveTo study the quantitative morphometric changes of corneal endothelial cells and to determine corneal thickness,glucose ratio of aqueous humor and plasma in type Ⅱ diabetes.Methods72 corneas taken from 36 patients of type Ⅱ diabetes and 36 corneas from normal persons were examined with non contact specular microscopy and quantitative morphometric analyses of individual endothelial cells.ResultsThe corneal endothelia of patients with type Ⅱ diabetes showed no significant differences in cell density,but demonstrated a significantly higher coefficient of variation,a decrease in percentage of hexagonal cells,a low figure coefficient and a higher percentage of non hexagonal cells,compared to those in the control group.ConclusionThe morphology of corneal endothelial cells of the patients with type Ⅱ diabetes,compared with the normal control,presented significantly abnormal.The abnormal morphology of corneal endothelium may result in the decrease in its stabillity and the increase in its vulnerability,which may be the important cause of postoperatively persistent edema of corneas.The impairment of blood aqueous barriers may lead to the increase of glucose in aqueous humor and cause the impairment of the corneal endothelium.

关 键 词：糖尿病 内皮细胞 角膜 形态学 

分 类 号：R771.3[医药卫生—眼科] R587.2[医药卫生—临床医学]