急性髓细胞白血病患者外周血及骨髓CD87表达的改变  

The difference between the expression of CD87 in peripheral blood and bone marrow on acute myeloid leukemia

作　　者：王娟[1] 张永菊[1] 许卫星[1] 沈杰[1] 王庆[1] 王瑞环[1] 张睿[1] 刘春燕[1] 

机构地区：[1]河北省沧州市中心医院血液科,061001

出　　处：《白血病．淋巴瘤》2008年第3期200-201,共2页Journal of Leukemia & Lymphoma

摘　　要：目的探讨急性髓细胞白血病（AML）患者外周血及骨髓CD87表达的改变。方法应用流式细胞术（FCM）检测了30例AML患者（M1 2例，M2 6例，M4 8例，M5 14例）外周血及骨髓CD87表达，应用配对t检验分析外周血及骨髓CD87表达的改变。结果14例M5患者骨髓CD87表达为9.47％～80.32％，外周血CD87表达为11.49％。87.46％；8例M4患者骨髓CD87表达为14．27％～46．28％，外周血CD。表达为14.79％～47.19％；6例M2患者骨髓CDg7表达为4．67％～34．26％，外周血CD＂表达为8.96％。39.78％；2例M，患者骨髓CDg7表达为3．56％～7.69％，外周血CDg7表达为5.21％～8.96％。30例急性髓细胞性白血病外周血及骨髓CD87表达差异有统计学意义（t=3．13，P〈0．05）。结论AML患者外周血及骨髓CD87表达有变化，外周血CD。表达高于骨髓，推荐应用外周血代替骨髓检测CD87表达。Objective The aim of the study was to explore the difference between the expression of CD87 in peripheral blood and bone marrow on acute myeloid leukemia （AML n=30）. Methods A flow cytometrie quantitative analysis of expression levels for CD87 was performed on fresh blast cells in peripheral blood and bone marrow from patients with acute myeloid leukaemia using CD87 monoclonal antibodies. Analysis the difference between the expression of CD87 using matched t -test. Results The values of CD87 expression in bone marrow of 14 M5 cases are from 9.47 %～80.32 %, and from 11.49 %～87.46 % in peripheral blood. The values of CD87 expression in bone marrow of 8 M4 cases are from 14.27 %～46.28 %,and from 14.79 %～47.19 % in peripheral blood. The values of CD87 expression in bone marrow of 6 M2 cases are from 4.67 %～34.26 %, and from 8.96 %～39.78 % in peripheral blood. The values of CD87 expression in bone marrow of 2 M1 cases are from 3.56 %～7.69 %, and from 5.21%～8.96 % in peripheral blood.The expression of CD87 in peripheral blood and bone marrow from patients with acute myeloid leukaemia had statistical difference （t =3.13, P 〈0.05）. Conclusion The levels of CD87 expression had difference between peripheral blood and bone marrow. The level in peripheral blood was higher than bone marrow. So when we performed quantitative analysis of expression levels for CD87, peripheral blood instead of bone marrow was commended.

关 键 词：白血病 粒细胞 急性 流式细胞术 尿纤溶酶原激活物 

分 类 号：R733.71[医药卫生—肿瘤]