抗心磷脂抗体与脑血管病关系的研究  

The study of the relationship between anticardiolipin antibodies and cerebrovascular disease

作　　者：许宏伟[1] 杨期东[1] 朱永辉 陈朝晖[1] 严斌[1] 

机构地区：[1]湖南医科大学湘雅医院神经病学研究所,长沙410008 [2]湖南省临湘市人民医院神经内科,长沙410008

出　　处：《脑与神经疾病杂志》1997年第6期331-333,共3页Journal of Brain and Nervous Diseases

摘　　要：目的探讨抗心磷脂抗体与脑血管病的关系．方法采用酶联免疫吸附试验对105例脑梗塞及48例脑出血患者的血清ACLA进行了检测，并与对照组50例结果进行比较。结果脑出血及脑梗塞组的ACLA阳性率明显高于对照组（P＜0．01），ACLA分型中，脑出血及脑梗塞组中的IgG型ACLA阳性率也明显高于对照组（P＜0．05，P＜0．01）．结论ACLA是脑出血及脑梗塞的危险因素，其中IgG型ACLA为主要致病性抗体。To identify the relationship between anticardiolipin antibodies and cerebrovascular diseases,the positive rates of anticardiolipin antibodies (ACLA) in plasma in 105 patients with cerebral infarction (CI), 48 Patients with cerebral haemorrhage (CH), and 50 control subjects were evaluated, using ELISA method. The results showed that the positive rates of ACLA in patients with CI, CH, and in control subjects were 43. 81 %, 39. 58%, and 16% respectively. The statistical significant differences among the CI group , the CH group and the control group were found for the positive rate of ACLA (P<0. 01). In the meantime, We found that the positive rates of IgG type ACLA were significantly higher in patients with CI and CH than in control subjects (P<0. 05, P< 0. 01 ). It was suggested that ACLA was an important risk factor for cerebrovascular diseases, IgG type ACLA was pathogenic autoantithey.

关 键 词：脑血管疾病 抗心磷脂抗体 病理 

分 类 号：R743.02[医药卫生—神经病学与精神病学]