脂膜超声造影剂增强兔肾VX2肿瘤显像及鉴别的实验研究  

Experimental study on lipid ultrasound contrast agent in imaging and differentiating renal VX2 carcinoma

作　　者：曾功君[1] 柳建华[1] 高云华[2] 刘政[2] 谭开彬[2] 吴梅[1] 

机构地区：[1]广州市第一人民医院功能检查科,广东广州510180 [2]第三军医大学新桥医院超声科,重庆400037

出　　处：《中国临床医学影像杂志》2008年第6期412-414,共3页Journal of China Clinic Medical Imaging

基　　金：广东省科委资助项目(2004B36001024)

摘　　要：目的:评价声学造影剂脂氟显对兔肾VX2肿瘤增强显像效果。方法:14只接种过VX2肾肿瘤的模型兔,经耳缘静脉团注脂氟显0.02ml/kg;使用二次谐波显像模式观察记录造影过程;用定性视觉评分和灰阶视频定量方法分析造影效果。结果:肿瘤视觉增强从5s开始,持续时间10～15min。视觉评分在造影后与造影前比较有显著差异。灰阶视频密度定量分析造影后VX2肿瘤灰阶值显著小于正常肾皮质(P<0.05)。结论:脂膜超声造影剂能有效增强兔肾VX2肿瘤显像,对假阳性有一定的鉴别诊断价值。Objective： To evaluate the imaging capability of lipid ultrasound contrast agent in imaging and differentiating renal VX2 carcinoma. Methods： Fourteen rabbits with VX2 carcinoma of left kidney were scanned by fundamental imaging and second harmonic imaging （SHI） after bolus injection of lipid ultrasound contrast agent （Zhifuxian 0.02ml/kg）. The contrastenhanced effect was estimated with qualitative vision and quantification gray-scale value. Results： The tumor was enhanced 5s after injection of ultrasound agent and lasted for 10-15 minutes. As to the qualitative vision there was statistically significant before and after contrast-enhanced. There was remarkable difference between renal cortex and renal tumor in gray-scale value after injection ultrasound agent. Conclusion： Lipid ultrasound contrast agent can effectively enhance the imaging of renal tumors and improve the detection of specificity.

关 键 词：肾肿瘤 超声检查 多普勒 彩色 造影剂 

分 类 号：R737.11[医药卫生—肿瘤] R445.1[医药卫生—临床医学]