多层螺旋CT灌注成像对肝癌TACE前后血供变化初步探讨  

Initial investigate of HCC blood supply before and after TACE using MSCT perfusion imaging

作　　者：陈光斌[1] 邹文远[1] 张桂华[1] 顾永丽[1] 张自力[1] 石思李[1] 李芳[2] 

机构地区：[1]湖北省郧阳医学院附属人民医院放射科,湖北十堰442000 [2]湖北省郧阳医学院附属人民医院肝病科,湖北十堰442000

出　　处：《医学影像学杂志》2008年第6期626-629,共4页Journal of Medical Imaging

基　　金：湖北省教育厅科研项目(项目编号:B200524015)

摘　　要：目的:探讨多层螺旋CT灌注成像在肝细胞癌(HCC)经导管动脉化疗栓塞术(TACE)前后血供变化。方法:对17例HCC患者于TACE前1天及治疗后7～10天行CT灌注扫描,测量肿瘤组织及正常肝组织灌注参数。结果:肿瘤组织TACE术前、术后HBF、HBV、HAP存在显著差异,MTT、PS、HAF、PVP无显著差异。正常组织TACE术前、术后各灌注参数无显著差异。结论:多层螺旋CT灌注成像对评价TACE疗效及指导进一步治疗有着重要价值。Objective：To investigate the blood supply changes of hepatoeellular carcinoma（HCC） before and after transcatheter arterial ehemoembolization（TACE） .Methods：MSCT perfusion scans were performed ld before treatment and 7 - 10d after TACE for 17 patients with HCC. The perfusion images and parameters of HCC lesions and normal lesions, par reactors such as the values of blood flow（BF）, blood volume（BV）, mean transit time（MTT）, permeabihty（is）, hepatic arterial fraction（HAF）, hepatic arterial perfusion（HAP）, partal vein peffusion（PVP） were worked out with liver tumor mode.Results：The defferences of HBF, HBV, HAP in HCC lesions were statistically significant, MTT, IS, HAF, PVP were not significant. All the defferences in normal lesions were not significant. Conclusion： MSCT perfusion imaging may be a safe and effective methods to evaluate the therapy effect of TACE and lead the next treatment.

关 键 词：肝细胞癌 经导管动脉化疗栓塞术 CT灌注成像 体层摄影术 X线计算机 

分 类 号：R735.7[医药卫生—肿瘤] R814.42[医药卫生—临床医学]