p63在肺癌微小活检组织标本中的应用价值  

Significance of p63 expression in small biopsy specimens of lung cancers

作　　者：李永纯[1] 杨虹[1] 贺志力[1] 卢德宏[1] 

机构地区：[1]首都医科大学宣武医院病理科,北京100053

出　　处：《诊断病理学杂志》2008年第3期191-193,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨p63及其与CK5/6、CK7联合应用在鉴别诊断肺微小活检组织标本鳞状细胞癌和腺癌中的作用。方法用SP法进行p63、CK5/6、CK7免疫组化染色,回顾观察47例已有相应肺癌根治切除标本证实其组织病理学类型的活检标本。结果鳞状细胞癌p63阳性率为96%(25/26),CK5/6为81%(21/26),CK7为4%(1/26);腺癌p63阳性率为5%(5/21),CK5/6为10%(2/21),CK7为95%(20/21)。结论p63对于诊断鳞状细胞癌有高度特异性,特别体现在微小组织活检标本上。联合应用p63、CK5/6、CK7有助于小块活检组织中肺鳞状细胞癌和腺癌的鉴别。Objective To investigate the importance of p63 and combined examination of p63, CK5/6 and CK7 expression in distinguishing between lung squamous cell carcinomas and adenocarcinomas in transbronchial biopsy specimens or some other small biopsies. Methods Using S-P immunohistochemical methods, we examined the expression of p63, CK5/6, CK7 in 47 eases of small specimens from primaty lung cancer, in which histological subtypes were confirmed by further examination of surgically removed specimens. Results The positive rate of p63 was 96% （25/26） in primaty lung squamous cell carcinoma. In contrast, adenocarcinomas were 5% （1/21）. The positive rates of CK5/6 expression were 81% （21/26） and 10% （2/21） in squamous cell carcinomas and adenocarcinomas of lung, respectively. The positive rates of CK7 expression were 4% （1/26） and 95 % （20/21） in squamous cell carcinomas and adenocarcinomas of lung, respectively. Conclusion p63 is an important marker for squamous cell carcinoma. Combined detection of p63, CK5/6 and CK7 is valuable in the differential diagnosis of lung squamous cell carcinoma from adenocarcinoma in small biopsy specimen.

关 键 词：肺癌 微小活检标本 免疫组化 P63 CK5/6 CK7 

分 类 号：R734.2[医药卫生—肿瘤]