uPA和LN-R在良、恶性甲状腺病变中的表达及临床病理意义  

Expression of uPA and LN-R in benign and malignant thyroid lesions and their clinicopathologic implications

作　　者：栾岚[1] 王翠芳[1] 滕猛[1] 

机构地区：[1]沈阳医学院奉天医院病理科,沈阳110024

出　　处：《诊断病理学杂志》2008年第3期224-227,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的研究uPA、LN-R在良、恶性甲状腺病变中的表达特点,并探讨其与甲状腺癌临床预后指数的关系。方法应用组织芯片和免疫组化检测28例结节性甲状腺肿、17例甲状腺滤泡性腺瘤、55例甲状腺乳头状癌、7例未分化癌、5例髓样癌、5例滤泡性癌、2例低分化岛状癌及1例鳞状细胞癌组织中uPA、LN-R的表达。结果uPA、LN-R在甲状腺癌中表达阳性率分别为80%和57.33%;在甲状腺良性病变中表达阳性率分别为6.67%和0。uPA、LN-R在欧洲癌症治疗研究组织(EORTC)预后指数不良组表达阳性率分别为91.49%和70.21%;在EORTC预后指数良好组表达阳性率分别为60.71%和35.71%。在甲状腺良、恶性病变中uPA和LN-R蛋白的表达呈显著正相关(χ2=26.194,r=0.467,P<0.01)。结论uPA、LN-R可以作为良、恶性甲状腺病变鉴别诊断的指标,也是判断甲状腺癌患者预后的指标。Objective To study the expression of uPA and LN-R in benign and malignant thyroid lesions, and to explore their relation with prognostic paraneters in thyroid carcinomas. Methods By means of tissue chip technique and the method, 28 cases of nodular goiters, 17 thyroid adenomas, 55 papillary carcinomas, 7 undifferentiated carcinoma, 5 medullary thyroid carcinoma, 5 follicular thyroid carcinomas, 2 poorly differentiated insular carcinoma and 1 thyroid squamous cell carcinoma were enrolled in this study to detect the expression of uPA and LN-R. Results The positive rates of uPA and LN-R were 80.00% and 57.33% in thyroid carcinomas, 6.67% and 0 in throid benign lesions, 91.49% and 70.21% in cases of EORTC with unfavorable prognosis, and 60.71% and 35.71% in cases of EORTC with favorable prognosis, respectively. Positive correlation was observed between the expression of uPA and LN-R protein （ x^2 = 26.194, r = 0.467, P 〈 0.001） Conclusion Immunohistochemical staining of uPA and LN-R can be an important adjunct to the histopathological diagnoses of thyroid lesions, and may be useful in evaluating the prognosis in patients with thyroid carcinomas.

关 键 词：甲状腺 癌 UPA LN—R 

分 类 号：R736.1[医药卫生—肿瘤]