犬尿氨酸代谢通路与中枢神经系统  

The Kynurenine Metabolic Pathway and the Central Nervous System

作　　者：李宁宁[1] 高平进[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院,上海市高血压研究所,上海市血管生物学重点实验室,200025

出　　处：《国际脑血管病杂志》2008年第5期388-392,共5页International Journal of Cerebrovascular Diseases

基　　金：国家重点基础研究发展计划“973”（No.2004CB518603）;国家自然科学基金（No.30600243）

摘　　要：犬尿氨酸代谢通路涉及一系列酶促反应，生成多种具有生物学活性的化合物，这些代谢产物统称为“犬尿氨酸能物质”。犬尿氨酸能物质参与多种病理生理学过程，在中枢神经系统中有着重要的生理功能。例如，喹啉酸是N-甲基-D-天冬氨酸受体激动剂，在许多感染性神经系统疾病中可大量堆积在中枢神经系统，导致神经元因兴奋性中毒而死亡。犬尿喹啉酸可拮抗兴奋性谷氨酸盐受体，减少因兴奋性中毒导致的神经元死亡。文章就犬尿氨酸代谢通路在中枢神经系统中作用的相关研究做了综述。The kynurenine metabolic pathway involves in a cascade of enzyme reaction generated multiple biologically-active compounds, These metabolites are called ＂kynurenines＂, which participate in diverse pathophysiological processes, particularly in the central nervous system. The kynurenines have important physiological functions. For example, quinolinic acid is an N-methyl-D-aspartate （NMDA） receptor agonist, and it can be largely accumulated in the central ner^us system in many infectious nervous system diseases, resulting in neuronal excitotoxicity and death. Kynurenic acid antagonizes excitatory glutamate receptors to reduce excitotoxicityinduced neuronal death. This article reviews the related researches of the effects of kynurenine metabolic pathway on the central nervous system.

关 键 词：犬尿氨酸 犬尿喹啉酸 喹啉酸 中枢神经系统 

分 类 号：R741[医药卫生—神经病学与精神病学]