慢性锑中毒患者细胞因子水平与抗氧化能力相关分析  

Study on relationship between cytokine and anti-lipid Peroxidation in chronicity Antimony Poisoning Patients

作　　者：刘瑛[1] 李溥[1] 黄月娜[2] 欧燕芳[2] 胡瑾 樊阳 

机构地区：[1]黔南民族医学高等专科学校生物化学教研室,贵州都匀558000 [2]黔南民族医学高等专科学校第二附属医院检验科,贵州都匀558000 [3]贵州瓮福矿区职工医院,贵州福泉550300

出　　处：《右江医学》2008年第3期247-249,共3页Chinese Youjiang Medical Journal

基　　金：贵州省卫生厅科技资助项目[黔卫发(2004)156号]

摘　　要：目的探讨慢性锑中毒患者细胞因子水平与抗氧化能力的相关性。方法对慢性锑中毒患者和对照组血清白细胞介素-2(IL-2)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平进行检测及分析。结果与对照组相比,慢性锑中毒患者血清IL-2I、L-8和TNF-α水平显著增高(P<0.01),SOD、GSH-Px活性明显降低,而MDA水平增高(P<0.01)。锑中毒患者IL-2I、L-8、TNF-α含量与SOD、GSH-Px活性呈负相关(P<0.01),与MDA水平呈正相关(P<0.01)。结论慢性锑中毒患者的细胞因子水平随抗氧化能力的降低而升高。Objective To study the relationship between cytokine levels and anti-LiPid peroxidation ability in chronicity Antimony Poisoning Patients. Methods Interleukin-2 （IL-2）,Interleukin-8（IL-8）, tumornecrosis factor-α （TNF-α）, superoxide dismutase（SOD）,glutathione peroxidase（GSH-px） and malondialdehyde（MDA）in the serum of patients with chronicity Antimony Poisoning were measured and analyzed. Results Comparing with those of the control group, the IL-2, IL-8,TNF-α, MDA levels were higher（ P 〈0.01 ）, while the SOD, GSH-Px Contents were lower （ P 〈0.01） in the patients chronicity Antimony Poisoning. there was a negative correlation between the content of IL-2,IL-8,TNF-α had a negative correlation with SOD,GSH-Px, while they had a significant positive correlation with MDA. Conclusion the eytokine levelswould increase as the decrease of anti-LiPid peroxidation ability in ehronieity Antimony Poisoning Patients.

关 键 词：慢性锑中毒 细胞因子 抗氧化能力 

分 类 号：R595[医药卫生—内科学]