CT引导下经皮微波凝固配合肝动脉化疗栓塞治疗肝癌100例  

Percutaneous microwave coagulation therapy combine with transcatheter arterial chemoembolization treating with hepatic carcinoma

作　　者：林宙[1] 杨维竹[1] 江娜[1] 黄兢姚[1] 黄宁[1] 申权[1] 

机构地区：[1]福建医科大学附属协和医院介入科,350001

出　　处：《福建医药杂志》2008年第3期4-7,F0003,共5页Fujian Medical Journal

基　　金：福建省卫生厅青年科研课题资助项目(2005-1-3)

摘　　要：目的评价经皮穿刺微波凝固治疗（PMCT）配合肝动脉化疗栓塞（TACE）治疗肝癌的疗效。方法100例肝癌共112个瘤灶采用CT引导下PMCT配合TACE治疗，并选择同期70例肝癌共92个瘤灶采用单纯TACE治疗作为对照。结果联合治疗组治疗后临床表现改善，大部分瘤灶明显缩小，缩小〉40％的占95．5％；活检提示36个≤3cm和17个〉3cm的瘤灶完全凝固性坏死，占47．32％；59个〉3cm的瘤灶大部分坏死，占52．68％。68例AFP升高者显著下降，25例转阴。全组病例均无严重并发症。随访1～24个月，3例死亡，2例复发，半年、1年、2年累计生存率分别为99．0％、98．0％、97．0％。与单纯TACE治疗组比较，肿瘤坏死率、瘤灶缩小率及患者生存率均明显提高（P〈0．05）。结论TACE配合PMCT治疗肝癌疗效好、肿瘤灭活彻底，可明显提高生存率,值得临床作讲一步研究。Objective To assess the clinical effect on percutaneous microwave coagulation therapy （PMCT） combined with transcatheter arterial chemoembolization treating with hepatic carcinoma. Methods 100 hepatic carcinoma patients about 112 tumor focuses treated with PMCT guide by CT combined with TACE. Then choose 70 paitents about 92 focuses treated with TACE only during in the same period to contrast. Results After the combined therapy, the clinical representation melio- rated in evidence, most of the tumor ranges had been prominency shrinked, tumors focuses diameter shrinked more than 40% occupied 95.5% in all, biopsy indicated that 36 tumor focuses diameter 43 cm and 17 focuses diameter 〉3 cm had completely putrescence, occupied 47.32%. Another 59 focuses had mostly putrescence, occupied 52.68%. 68 patients with high AFP level had prominence reduced, 25 patients had turned to normal. Accessing one to 24 months, three paitents dead, two paitents recrudesce, and there was no severe complication occurred too. The cumulate survival rate of all patients in half, one or two years were 99.0 %0, 98.0 %0 and 97.0 %. Compared with the only TACE treated group, the tumor putrescence and shrinked rate, besides the patients survival rate were patency higher （P〈0. 05）. Conclusions PMCT combined with TACE treating with hepatic carcinoma is a more effective method to improve patients survival rate, to kill tumor more completely and it＇s deserve us to go forther studing.

关 键 词：癌 肝脏 微波凝固 化疗栓塞 

分 类 号：R735.7[医药卫生—肿瘤]