槲皮素-3’-氨基酸酯盐酸盐的合成工艺研究  

Study on the synthesis of 3'-amino carboxylate hydrochloride of quercetin

作　　者：于姝燕[1] 杨跃[1] 郑永胜[1] 郭举[1] 吴成龙[1] 罗娟[2] 田之悦[2] 成丽[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学化学学院,四川成都610065

出　　处：《化学研究与应用》2008年第5期631-635,共5页Chemical Research and Application

基　　金：四川省科技厅(06J13-008-1)资助项目

摘　　要：The synthetic route of 3’-amino carboxylate hydrochloride of quercetin is improved.Using benzyl bromide to partly protect the hydroxyl groups,the protected quercetin then react with a series of Boc protected amino acids to afford the 3’-amino carboxylate,hydrogenised and treated with HCl(g),a series of 3’-amino carboxylate hydrochloride of quercetin are synthesized in good yields.The structures of these compounds are confirmed by means of their m.p.,mass spectra and 1H NMR.The synthetic route of 3＇-amino carboxylate hydrochloride of quereetin is improved. Using benzyl bromide to partly protect the hydroxyl groups,the protected quereetin then react with a series of Boe protected amino acids to afford the 3 ＇ -amino earboxylate, hydrogenised and treated with HCl （g）, a series of 3＇ -amino earboxylate hydroehloride of quereetin are synthesized in good yields. The structures of these compounds are confirmed by means of their m. p. ,mass spectra and ^1H NMR.

关 键 词：槲皮素 溴化苄 槲皮素-3’-氨基酸酯盐酸盐 

分 类 号：O621.3[理学—有机化学]