胃癌组织TGF-β1、TGF-βRⅡ、p27^(kipl)的表达水平及临床意义  

The Expressions and Prognostic Significance of TGF-β1 and TGF-βR II and p27^(Kip1) in the Gastric Carcinoma

作　　者：万昌武[1] 胡军[1] 刘启兰[1] 

机构地区：[1]贵阳医学院病理学教研室,550004

出　　处：《贵州医药》2008年第4期299-301,共3页Guizhou Medical Journal

摘　　要：目的探讨胃癌组织TGF-βRⅡ及p27kipl表达水平与临床病理因素间的关系。方法采用免疫组化EnVision二步法对胃癌组织、切端胃粘膜组织进行GF-βRⅡ及p27kipl染色,图像分析系统测定癌组织、邻癌粘膜组织及切端粘膜组织的实质细胞数和阳性细胞数,计算阳性细胞比率。结果癌组织TGF-β1表达水平高于切端粘膜组织,p27kipl及GF-βRⅡ的表达水平低于切端粘膜组织。p27kipl与GF-βRⅡ两者间表达水平呈正相关。p27kipl表达水平与肿瘤的分化程度、浸润深度及淋巴结转移相关GF-βRⅡ表达水平与肿瘤的浸润深度相关。结论胃癌组织TGF-βRⅡ、p27kipl表达显著降低,并与胃癌的一些临床病理因素相关;TGF-β1表达增高并可能通过GF-βRⅡ、p27kipl等对肿瘤的生物学行为产生影响,对相邻上皮细胞的恶性转化可能也有促进作用。Objective To investigate the expression level and their prognostic significance of TGF-β1, TGF-βRII and p27^kipl were detected by using two-step Methods of EnVision immunohistochemical system. And image analysis was employed to measure the number of parenchyma cells and the positive cells, and to calculate the positive ratio respectively. Results Compared with those in distant normal mucosa, the expression levels of TGF-βRII and p27^Kipl decreased in the tumor tissue and the adjacent mucosa, while that of TGF-β1 increased. The expression of p27^kipl correlated positively with that of TGF-βRIL Conclusion The expression levels of TGF-βR II and p27^kipl decrease obviously in the tumor tissue, and is related with some clinicopathological features. The over expression of TGF- β1 take the influence possibly to the tumor biology behavior through TGF-βRII and p27^Kipl, and may be promote malignancy transform also of the adjacent epithelial cell.

关 键 词：胃癌 转化生长因子-Β1 转化生长因子受体Ⅱ P27^KIPL 免疫组织化学 

分 类 号：R730.2[医药卫生—肿瘤]