西酞普兰与氟西汀治疗脑卒中后抑郁症对照研究  

A control study of citalopram and fluoxtine in the treatment of poststroke depression

作　　者：王绪芸[1] 

机构地区：[1]山东省烟台毓璜顶医院,264000

出　　处：《中国现代药物应用》2008年第13期32-33,共2页Chinese Journal of Modern Drug Application

摘　　要：目的比较研究西酞普兰与氟西汀治疗脑卒中后抑郁症的效果和安全性。方法将符合标准的脑卒中后抑郁症患者随机分为西酞普兰和氟西汀两组分别进行治疗,用汉密顿抑郁量表(HAMD)和副反应量表(TESS)对治疗前后的情况进行比较分析。结果西酞普兰与氟西汀两组患者在治疗前与治疗后第2、4、6周HAMD评分有显著性差异,而两组之间无差异。西酞普兰治疗脑卒中后抑郁症的有效率和显效率与氟西汀接近。治疗后西酞普兰组与氟西汀组TESS评分无显著性差异。结论西酞普兰有较好的抗抑郁作用,无严重不良反应,可以作为治疗脑卒中后抑郁症的安全、有效的药物。Objective To study the efficacy and safety of citalopram and fluoxtine in the treatment of poststroke depression. Methods Patients with diagnosis of poststroke depression and fulfilling the admission criteria to the study were randomly assigned to two groups that were treated with citalopram and fluoxtine. The therapeutic responses were evaluated with HAMD and TESS. Results There were significant differences with HAMD between before and after the treatment of both citalopram and fluoxtine. The effect of citalopram treating poststroke depression were equal with that of fluoxtine. There were little difference with TESS between reboxetine and fluoxtine. Conclusions Citalopram has the effect of anti-depression and little severity adverse effect, so it can be a effective and safe drug to treat poststroke depression.

关 键 词：脑卒中后抑郁症 西酞普兰 氟西汀 对照研究 

分 类 号：R749.1[医药卫生—神经病学与精神病学]