介入化疗治疗晚期恶性胰岛细胞瘤：附4例报道  

Transcatheter arterial infusing chemotherapy for advanced malignant pancreatic islet cell tumors: four cases report

作　　者：郑家平[1] 邵国良[1] 俞炎平[1] 张家兴[2] 顾伟中[2] 

机构地区：[1]杭州浙江省肿瘤医院介入病区,310022 [2]同济大学附属上海第十人民医院介入科

出　　处：《介入放射学杂志》2008年第6期408-410,共3页Journal of Interventional Radiology

摘　　要：目的探讨经导管动脉内灌注化疗(TAI)治疗晚期恶性胰岛细胞瘤的近期疗效。方法4例经病理证实晚期恶性胰岛细胞瘤,原发灶位于胰颈部1例,胰体尾部3例。3例为恶性胰岛素瘤伴有肝脏弥漫、多发转移,1例无功能恶性胰岛细胞瘤,因肿瘤侵及周围大血管和脾脏无法切除。4例患者接受腹腔干TAI,其中对3例肝脏转移瘤进行化疗栓塞。间隔1～2个月重复治疗。结果4例患者均获得随访,接受介入化疗共11疗程,平均2.8疗程。随访2～8个月,原发肿瘤部分缓解(PR)3例,稳定(SD)1例;转移瘤PR4例。伴有低血糖恶性胰岛素瘤患者空腹血糖全部恢复正常水平,1例无功能恶性胰岛细胞瘤临床腹胀、腹痛缓解。介入术后出现一过性发热3例,余未见介入化疗相关不良反应。结论对外科无法切除晚期恶性胰岛细胞瘤行TAI安全、疗效良好。Objective To explore the clinical efficacy of transcatheter arterial infusion （TAI） chemotherapy for advanced malignant pancreatic islet cell tumors. Methods Four patients（3 malignant insulin tumors, 1 non-functional malignant pancreatic islet cell tumor）with unresectable advanced malignant tumors were carried out TAI via celiac artery, The three malignant insulin tumors with multiple hepatic metastases were further performed with transcatheter arterial chemoembolization （TACE）. The therapeutic cycles were repeated with intervals of 1 - 2 months. Results Eleven therapeutic cycles （mean 2.8）were accomplished in 4 cases. Follow-up for 2 - 8 months, the clinical PR were achieved in three cases, furthermore with SD in one case. The clinical uprising blood glucose became normal in all three cases, and the abdominal distention and bellyache were relieved in the patient with non-functional malignant pancreatic islet cell tumor. No serious adverse effects occurred. Conclusions TAI for unresectable advanced malignant pancreatic islet cell tumors is safe and effective.

关 键 词：胰岛细胞瘤 恶性 动脉内灌注化疗 介入治疗 

分 类 号：R736.7[医药卫生—肿瘤]