卵圆细胞的生物学特征及其与肝癌发生的关系  

Molecular Biologic Characteristics and Relationship with Hepatocarcinogenesis of Oval Cells

作　　者：陈琼荣[1] 向景[2] 刘清波[3] 赵国强[3] 车丽洪[3] 

机构地区：[1]湖北省肿瘤医院病理科,武汉430079 [2]中山大学附属肿瘤医院病理科 [3]中山大学第一附属医院病理科

出　　处：《肿瘤防治研究》2008年第6期390-393,共4页Cancer Research on Prevention and Treatment

摘　　要：目的通过动态的方法观察卵圆细胞的主要生物学特征及其在肝癌发生过程中的演变规律,揭示卵圆细胞与肝癌发生之间的关系。方法构建实验性肝癌的大鼠诱癌模型,运用常规HE染色、免疫组织化学和爱新蓝染色等方法,动态观察卵圆细胞在肝癌发生过程中的演变规律和分子表达特征。结果随着诱癌时间延长,逐渐出现卵圆细胞的增生、癌前病变、胆管细胞癌和(或)肝细胞癌,各阶段卵圆细胞均表达OV-6、AFP和c-kit。结论原发性肝癌可能与卵圆细胞异常分化有关,卵圆细胞特征性表达为OV-6、AFP和c-kit。Objective To detect the major biologic characteristics of oval cells, and to explore its correlation to hepatocarcinoma through dynamic observation on evolutive law of the oval cells in experimental hepatocarcinogenesis. Methods By constructing the experimental liver cancer models and using techniques including routine HE stain, alcian blue stain and immunohistochemistry to observe the major biologic characteristics of the oval cells and the law of evolution in hepatocarcinogenesis. Results Along with the prolonging of cancer-induction, the oval cells proliferated gradually, then come forth precancerous lesions, and became hepatocellular and （or） cholangiocellular carcinoma. OV-6, AFP and c-kit were expressed in all oval cells in every period. Conclusion Associated with abnormal differentiation of oval cells maybe associated with primary liver cancer, and the oval cells express OV-6, AFP and c-kit characteristically.

关 键 词：原发性肝癌 卵圆细胞 生物学特征 肝癌发生 

分 类 号：R735.7[医药卫生—肿瘤]