Survivin和Smac在肝外胆管癌中的表达  

Survivin and Smac Expression in Extrahepatic Biliary Tract Carcinoma

作　　者：李胜棉[1] 康惠贞[1] 王小玲[2] 王士杰[3] 

机构地区：[1]河北医科大学第四医院消化科,石家庄050011 [2]河北医科大学第四医院病理科,石家庄050011 [3]河北医科大学第四医院内镜室,石家庄050011

出　　处：《肿瘤防治研究》2008年第6期418-421,共4页Cancer Research on Prevention and Treatment

基　　金：河北省普通高等学校强势特色学科基金资助项目(200552);国家教育部留学回国人员启动基金资金资助项目(200555)

摘　　要：目的探讨Survivin和Smac在肝外胆管癌发生发展中的作用和意义。方法27例肝外胆管癌、10例异型增生组织和5例正常上皮组织,均行免疫组化染色检测Survivin和Smac的表达。半定量法结果评价,统计学方法分析比较。结果Survivin在肝外胆管正常上皮组织、异型增生组织和癌组织中阳性表达率分别为20%、50%和74.1%,正常胆管上皮组织和癌组织中Survivin表达差异有统计学意义(P=0.037)。Smac在肝外胆管正常上皮组织、异型增生组织和癌组织中阳性表达率分别为40%、50%和85.2%,异型增生组织和癌组织中表达差异有统计学意义(P=0.041)。Survivin和Smac的表达与肝外胆管癌组织病理学特征和临床分期无关。结论Survivin和Smac凋亡相关基因参与了肝外胆管癌的发生发展,可能在由正常上皮组织向异型增生再向癌的恶性转化过程中起重要作用。Objective To investigate the expression of Survivin and Smac and evaluate whether Survivin and Smac protein play a role in the progression from normal epithelium to dysplasia to carcinoma of extrahepatic biliary tract. Methods The expressions of Survivin and Smac were examined immunohistochemically in 27 specimens surgically removed extrahepatic biliary tract carcinoma, ten cases of dysplasia lesions and 5 cases of normal epithelial tissues. Results Survivin protein expression was found in 20 of 27 （74. 1 %） invasive carcinoma, 5 of 10 （50% ） dysplasia lesions and 1 of 5 （20 % ） normal epithelium. The difference of Survivin expression between invasive carcinoma and normal epithelium was significant （P = 0. 037）. For Smac protein expression, positive rate of expression was 23/27（85.2% ） in invasive carcinoma, 5/10 （50%） in dysplasia lesions and 2/5（40%） in normal epithelium. The difference of Smac expression between dysplasia lesions and invasive carcinoma was significant （P = 0. 041 ）. There was no significance between Survivin expression and histopathological features or clinical stages in invasive carcinoma, neither was Smac. Conclusion The increased tendency of Survivin and Smac expression in dysplasiacarcinoma sequence of extrahepatic biliary tract indicates Survivin and Smac may be involved in neoplastic development.

关 键 词：肝外胆管癌 异型增生 SURVIVIN SMAC 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]