皮肤恶性黑色素瘤中整合素连接激酶的表达  

Expressions of ILK in cutaneous malignant melanoma

作　　者：花象锋[1] 肖明明[2] 郑静[2] 景士兵[2] 

机构地区：[1]辽宁省人民医院妇产科,辽宁沈阳110016 [2]辽宁省人民医院病理科,辽宁沈阳110016

出　　处：《中国美容整形外科杂志》2008年第3期224-226,共3页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的探讨对原发性皮肤恶性黑色素瘤(CMM)及转移性恶性黑色素瘤(MM)中整合素连接激酶(ILK)的表达情况。方法采用免疫组化技术(SP法)检测ILK在42例CMM和37例转移性MM手术切除标本及15例CMM门诊活检标本中的表达情况。42例CMM中,伴淋巴结转移25例,无转移17例。结果发育不良痣与良性痣相比,ILK的阳性表达率有显著差异(P<0.05);而良性痣与正常皮肤之间的差异,均无统计学意义(P>0.05)。CMM中ILK的阳性表达率显著高于发育不良痣。转移性MM中ILK的阳性表达率均显著高于CMM。结论各种痣中ILK阳性细胞可能已具有演变为MM的潜能,追踪ILK阳性痣的病变将有助于早期发现MM;此外,ILK的阴性表达与clark病理分级呈正相关,说明ILK在MM的浸润及转移过程中亦起到关键性作用。Objective To expore the expression of ILK in cutaneous malignant melanoma （CMM） and metastatic melanoma（MM）. Methods Immunohistoehemistry（S-Pmethod） was used to detect the expression of lLK in 42 cases of CMM. Thirty seven cases with metastatic MM were obtained from operations and 15 eases with CMM were obtained from clinical biopsy specimes. Twenty - five of 42 cases of CMM had lymph node metastasis, and the remainder were without lymph node metastases. Results Compared with expression of ILK in benign nevus, the positive expression of ILK in dysplastic nevus showed significant deviation. However, expression of ILK in benign nevus and normal skin did not show significant deviation. The positive expression of ILK in CMM was stronger than that in dysplastic nevus, And in turn expression in metastatic MM was stronger than that in CMM. Conclusion ILK positive cells in various kinds of nevi may have the potential to develop MM. Tracking ILK positive nevi may be helpful for early indentification of MM, In addition, positive expression of ILK was tic, ely correlated with Clark＇s pathological stage of MM. ILK may play an important role in the process of infiltration and spread of MM.

关 键 词：ILK CMM MM 免疫组织化学 

分 类 号：R739.5[医药卫生—肿瘤]