畲族Gc、PGM1、AcP_1、6-ΡGD、ADA和AK1的遗传多态性  

GENETIC POLYMORPHISM OF Gc,PGM1,AcP 1,6 PGD, ADA AND AK1 IN SHE ETHNIC GROUP IN CHINA

作　　者：卓孝福[1] 郭永建[1] 戴庚孙[1] 尹学念[2] 徐玖瑾[3] 杜若甫[3] 

机构地区：[1]福建医科大学检验系 [2]吉林医学院免疫教研室 [3]中国科学院遗传研究所

出　　处：《人类学学报》1997年第4期262-270,共9页Acta Anthropologica Sinica

摘　　要：对畲族血浆组特异性成分（Ｇｃ）、红细胞磷酸葡萄糖变位酶１（ＰＧＭ１）、酸性磷酸酶（ＡｃＰ１）、６－磷酸葡萄糖酸脱氢酶（６－ＰＧＤ）、腺苷脱氨酶（ＡＤＡ）、腺苷酸激酶（ＡＫ１）的遗传多态性进行了研究。Ｇｃ与ＰＧＭ１是用薄层聚丙烯酰胺凝胶等电聚焦分析的，ＡｃＰ１、６－ＰＧＤ、ＡＤＡ及ＡＫ１是用淀粉凝胶电泳分析的。各基因座的基因频率分别为Ｇｃ＊１Ｆ０．４７２２、Ｇｃ＊１Ｓ０．２４２１、Ｇｃ＊２０．２７３８；ＰＧＭ１＊１Ａ０．５３５７、ＰＧＭ１＊１Ｂ０．１６２７、ＰＧＭ１＊２Ａ０．１５８７、ＰＧＭ１＊２Ｂ０．１４２９；ＡｃＰ＊１Ａ０．１８２５、ＡｃＰ１＊Ｂ０．８１７５；６－ＰＧＤ＊Ａ０．９６８３、６－ＰＧＤ＊Ｂ０．０２７８；ＡＤＡ＊１０．９８８１、ＡＤＡ＊２０．０１１９；ＡＫ１＊１１．００００。畲族Ｇｃ、ＰＧＭ１、ＡｃＰ１、６－ＰＧＤ和ＡＤＡ基因为多态，而ＡＫ１基因为单态。发现１例带有６－ＰＧＤ＊Ｒ和３例带有Ｇｃ＊１Ａ２变异等位基因的个体，其中Ｇｃ＊１Ａ２基因频率为０．０１１９，达到多态水平。The genentic polymorphism of Gc and PGM1 was studied with thin layer polyacryamide gel isoelectric focusing (PAG IEF) and that of AcP 1,6 PGD,ADA,and AK1 with starch gel electrophoresis combined with specific staining in She ethnic group in Fujian Province. Their gene frequencies obtained are:Gc 1F 0 4722,Gc 1S 0 2421,Gc 2 0 2738;PGM1 1A 0 5357,PGM1 1B 0 1627,PGM1 2A 0 1587,PGM1 2B 0 1429;AcP 1 A 0 1825,AcP 1 B 0 8175;6 PGD A 0 9683,6 PGD B 0 0278;ADA 1 0 9881,ADA 2 0 0119;and AK1 1 1 0000. There is monomorphism in locus of AK1 in She population. Three cases with rare variant allele (Gc 1A2) were found in Gc with a frequency of 0 0119,and one case with 6 PGD R in 6 PGD.

关 键 词：人类遗传学 遗传多态性 畲族 组特异性成分 酶类 

分 类 号：Q987[生物学—遗传学]