GC/MS和GC法定性定量分析可卡因  

Qualitative and quantitative analysis of cocaine by GC/MS and GC

作　　者：蹇斌[1] 朱军[2] 崔巍[2] 赵敬真[2] 刘耀[2] 

机构地区：[1]中国人民公安大学研究生部,北京100038 [2]公安部物证鉴定中心,北京100038

出　　处：《中国法医学杂志》2008年第3期166-168,共3页Chinese Journal of Forensic Medicine

摘　　要：目的建立用于可卡因案件检验鉴定的GC和GC/MS定性、定量分析方法。方法通过选择和优化,建立GC、GC/MS法检验可卡因的最佳分析条件;用分别含0.6mg/ml地西泮为内标的0.10、0.20、0.40、0.60、0.80、1.00、1.20mg/ml可卡因标准品乙醇液,考察线性范围和方法检测限。结果分析方法线性方程:GC/FID,Y=1.055X-0.0021,R2=0.9999,GC/NPD,Y=0.556X-0.0016,R2=0.9996;可卡因检测限:GC/FID法10ng,GC/NPD法2ng;分别以所建GC/FID、GC/NPD分析方法和内标法对案件中缴获的可卡因毒品进行定量分析,结果为72%±2.3%,且两方法定量重现性良好。结论本文所建方法可以用于可卡因涉毒案件的检验鉴定。Objective To establish GC and GC/MS qualitative and quantitative analysis methods for identification of cocaine cases. Methods Choosed and optimized the best analysis parameters of cocaine by GC/MS and GC. We prepared 0.10, 0.20, 0.40, 0.60, 0.80, 1.00, 1.20mg/ml ethanol solution of cocaine standard which all contained 0.6mg/ml diazepam （internal standard） to study the analyse standard curve and the detection limit of cocaine drugs. Results The linear equation of cocaine by GC/FID was Y = 1. 055X - 0. 0021, R2 = 0.9999 ; That of GC/NPD was Y = 0.556X - 0.0016, R2 = 0.9996 ; The detection limits of cocaine were 10ng by GC/FID method and 2ng by GC/NPD method. On the other hand, we used GC/FID and GC/NPD methods and internal standard to quantitate the cocaine drugs sized by police respectively, the result of concentration was 72% ± 2.3%. The quantitative data of both methods had good repeatability. Conclusion The methods established are useful to examine and identify cases of cocaine.

关 键 词：法医毒物学 可卡因 定性定量分析 GC GC/MS 

分 类 号：D919.1[医药卫生—法医学]