HPLC法测定复方对乙酰氨基酚片中3种成分的含量  

Determination of Paracetamol,Caffeine and Aspirin in Compound Paracetamol Tablets by HPLC

作　　者：杨永刚 王震红 陈垠杉 

机构地区：[1]辽宁省药品检验所,沈阳110023 [2]沈阳市第二十中学

出　　处：《中国药事》2008年第6期483-484,共2页Chinese Pharmaceutical Affairs

摘　　要：建立HPLC法测定复方对乙酰氨基酚片中对乙酰氨基酚、咖啡因和乙酰水杨酸的含量;用Kromasil C18色谱柱;流动相为甲醇-0.2%庚烷磺酸钠溶液(15∶85)冰醋酸调pH值3.4,流速:1.0mL·min-1;检测波长为280nm。本方法简便、准确、灵敏度高、重现性好,可更好地控制本品的质量。A method for the determination of Paraeetamol, Caffeine and Aspirin in Compound Paraeetamol Tablets by HPLC was established. The Kromasil C18 column was used, the mobile phase was methanol-0. 2% sodium heptanesulfonate solution （15 ： 85） （the pH of mobile phase was adjusted to 3.4 with acetic acid glacial）. The detection wavelength was 280nm, the flow was 1.0mL·min^-1. The method is simple, accurate, highly serious and reproducible, It can provide a reference standard for the quality control of Ankahuangmin Capsules.

关 键 词：复方对乙酰氨基酚片 对乙酰氨基酚 咖啡因 乙酰水杨酸 含量测定 

分 类 号：R927.2[医药卫生—药学]